Blood manganese levels and glycosylation changes of subject B during manganese therapy. Subject B did not receive galactose substitution but was started directly on manganese therapy. Glycosylation improved during MnSO4· H2O. The final dose of 600 mg MnSO4· H2O resulted in physiological manganese concentrations in whole-blood samples and trisialo-transferrin within normal ranges. A full color version of this figure is available at the Genetics in Medicine journal online.