Electroencephalography of subject A during manganese supplementation. (a) At the initial presentation, the subject suffered from severe infantile seizures with hypsarrhythmia. (b) Intensive anticonvulsive therapy with prednisolone, vigabatrin, and phenobarbital was not able to control the seizures. Correspondingly, electroencephalogram revealed prominent right hemispheric spike wave complexes indicating strong susceptibility to seizures. (c) At day 206 of manganese therapy, electroencephalogram recording when sleeping showed no susceptibility to seizures as well as predominant alpha activity at 8 Hz. (d) Electroencephalogram recording when awake at day 318 showed isolated sharp waves over the temporo-occipital region. A full color version of this figure is available at the Genetics in Medicine journal online.