Blood manganese levels of subject A. Blood levels of manganese during supplementation with reference ranges (7–11 ng/ml) indicated in green. At a dose of 200 mg MnSO4 · H2O/d, stable physiological levels of manganese were reached. Reference ranges for manganese in whole-blood samples were not surpassed at any time. A full color version of this figure is available at the Genetics in Medicine journal online.