Figure 2 | Genetics in Medicine

Figure 2

From: Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations

Figure 2

Maximum likelihood phylogenetic tree of NPC1 proteins and described sets. The star is placed at the root of full-length NPC1. On the left side, the black markers represent the closest NPC1 to the root for each organism. Green markers (Sets 1 and 2) show the orthologs, whereas red markers point to paralogs. Blue markers represent sequences that are ambiguous in terms of orthology. The gray-shaded clade contains a short version of NPC1. Set 1, which contains the HsNPC1 orthologs after the most recent duplication, is a subset of Set 2.

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