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Association of IRF5 polymorphism with MPO–ANCA-positive vasculitis in a Japanese population

Genes & Immunity volume 14, pages 527–529 (2013)Cite this article

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Abstract

Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases. In this study, we investigated whether these genes also contribute to susceptibility to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. A case–control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)–ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. IRF5 rs10954213G was significantly increased in MPO–ANCA-positive AAV (additive model, P=0.023, odds ratio=1.27, 95% confidence interval=1.03–1.57). The risk allele was previously shown to be associated with lower mRNA level of IRF5. On the other hand, significant association of STAT4 rs7574865T with AAV was not detected. These observations suggested that IRF5 may contribute to susceptibility to MPO–ANCA-positive AAV in a Japanese population.

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Acknowledgements

This work was supported by Grant-in-Aid for Scientific Research (B) (22390199), Grant-in-Aid for Challenging Exploratory Research (23659495) and Grant-in-Aid for Young Scientists (B) (23791101) from the Japan Society for the Promotion of Science (JSPS), Health and Labour Science Research Grants for Research on rare and intractable diseases from the Ministry of Health, Labour and Welfare of Japan, and the Japan Allergy Foundation and SENSHIN Medical Research Foundation.

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Authors and Affiliations

  1. Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    A Kawasaki & N Tsuchiya

  2. School of Medicine, University of Tsukuba, Tsukuba, Japan

    A Kawasaki, N Inoue, C Ajimi & N Tsuchiya

  3. Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    K-e Sada & H Makino

  4. Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan

    S Kobayashi

  5. Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan

    H Yamada & S Ozaki

  6. Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan

    H Furukawa & S Tohma

  7. Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    T Sumida

  8. Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    N Miyasaka

  9. Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    S Matsuo

  10. Juntendo University School of Medicine, Tokyo, Japan

    H Hashimoto

  11. Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    M Harigai

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  1. A Kawasaki
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  2. N Inoue
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  9. S Tohma
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  10. N Miyasaka
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  13. H Hashimoto
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  14. H Makino
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  15. M Harigai
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  16. N Tsuchiya
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Correspondence to N Tsuchiya.

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Kawasaki, A., Inoue, N., Ajimi, C. et al. Association of IRF5 polymorphism with MPO–ANCA-positive vasculitis in a Japanese population. Genes Immun 14, 527–529 (2013). https://doi.org/10.1038/gene.2013.45

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  • DOI: https://doi.org/10.1038/gene.2013.45

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