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No association of primary Sjögren’s syndrome with Fcγ receptor gene variants


The genetic background of primary Sjögren’s syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcγ receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fcγ receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N=527) and controls (N=528) were genotyped for the Fcγ receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in 478 cases and 455 controls, using TaqMan SNP genotyping assays. FCGR3B CNV was analysed in 124 patients and 139 controls using a TaqMan copy number assay. None of the SNPs showed any association with pSS. Also, no FCGR3B CNV association was detected. The lack of association of pSS with Fcγ receptor gene variants indicates that defective immune complex clearance may not be as important in pSS pathogenesis as in SLE, and may point to important differences between SLE and pSS.

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We thank Marianne Eidsheim and Dagny Ann Sandnes from the Broegelmann Research Laboratory, University of Bergen, for excellent technical assistance. Genotyping of rs1801274 was performed by the SNP&SEQ Technology Platform in Uppsala, Sweden. Isolation and storage of some of the Swedish DNA samples were performed by Region Skåne’s Competence Centre for Clinical Research, RSKC. The Malmö Diet and Cancer Study/Malmö Preventive Medicine program provided the population-based cohort from which the Malmö controls originated. The Malmö controls consisted of a population-based cohort included in the Malmö Cost-Cancer registry. The controls from Stockholm were samples from the population-based Epidemiological Investigation of Rheumatoid Arthritis (EIRA) control cohort. This work was supported by the University of Bergen; the Strategic Research Program at Helse Bergen; the Western Norway Regional Health Authority (Helse Vest) and the Broegelmann Foundation, Bergen, Norway. Also, the Swedish Research Council, the Swedish Rheumatism Foundation, King Gustaf V’s 80-year Foundation, Ragnar Söderberg Foundation and COMBINE. The SNP Technology Platform in Uppsala, Sweden, was established by funding from the Knut and Alice Wallenberg Foundation.

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Correspondence to K Haldorsen.

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Haldorsen, K., Appel, S., Le Hellard, S. et al. No association of primary Sjögren’s syndrome with Fcγ receptor gene variants. Genes Immun 14, 234–237 (2013).

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  • Sjögren’s syndrome
  • Fc gamma receptors
  • single-nucleotide polymorphism
  • DNA copy number variations

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