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Lupus-prone strains vary in susceptibility to antibody-mediated end organ disease

Genes & Immunity volume 14, pages 170–178 (2013)Cite this article

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Abstract

Renal involvement is the major cause of morbidity and mortality in lupus. Besides autoantibodies, intrinsic renal factors may contribute to the susceptibility to lupus nephritis. To determine how different mouse strains that develop spontaneous lupus fare in their susceptibility to immune mediated nephritis, mice from six lupus-prone strains and two non-lupus control strains (B6 and BALB/c) were challenged with rabbit anti-GBM sera. Among the strains tested, NZM2410 (or NZM) mice developed severe glomerulonephritis (GN), whereas BXSB and B6.lpr, NZB mice were relatively resistant to anti-GBM disease, as were the BALB/c controls. BWF1 and B6.Yaa mice exhibited intermediate degrees of GN that was comparable to the B6 controls. The severity of the renal disease in these strains did not appear to be related to the degree of the systemic immune response to the administered rabbit Ig. In addition, cytokine profiling demonstrated differential urinary excretion of several molecules in the NZM mice, compared with the controls. Together with our previous reports, our studies demonstrate that lupus-prone strains vary in their susceptibility to immune mediated nephritis, despite similar levels of circulating autoantibodies and comparable degrees of immune complex deposition in the kidneys.

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Acknowledgements

Dr Chun Xie and Dr Kirthi Raman Kumar were supported by the National Arthritis Foundation. This work was support in part by an NIH grant.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, The University of Texas, Southwestern Medical Center, Dallas, TX, USA

    C Xie, Y Du, K Kumar, L Li, J Han, K Liu & C Mohan

  2. Department of Internal Medicine, Division of Nephrology, The University of Texas, Southwestern Medical Center, Dallas, TX, USA

    C Xie

  3. Department of Pathology, The University of Texas, Southwestern Medical Center, Dallas, TX, USA

    X J Zhou

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  1. C Xie
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Correspondence to C Mohan.

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Xie, C., Du, Y., Kumar, K. et al. Lupus-prone strains vary in susceptibility to antibody-mediated end organ disease. Genes Immun 14, 170–178 (2013). https://doi.org/10.1038/gene.2012.57

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