Figure 1

From: Host gene-encoded severe lung TB: from genes to the potential pathways

Figure 1

TB patients carrying the two-locus genotype −2518 MCP-1GG and −1607 MMP-1 2G/2G express MCP-1, MMP-1 and MMP-9. We used double IHC analysis of MCP-1, MMP-1 or MMP-9 and CD68 in paraffin-embedded diseased lung from six TB patients who underwent surgery to remove damaged tissue. We are showing representative data. (a) Negative control (irrelevant antibodies isotype control). (b) MCP-1 (blue) and CD68 (red). (c) MMP-1 (blue) and CD68 (light red) (d) MMP-9 (blue) and CD68 (light red). Images were acquired at × 200 total magnification. IHC analysis shows granulomas with CD68-positive cells (macrophages) expressing copious amounts of MCP-1, MMP-1 and MMP-9.