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Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population

Abstract

The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.

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Acknowledgements

This study was partly supported by a grant from the National Institute of Health (2RO1HD37800, 4R33DK069878, 4R33HD050196) (JXS) and the Juvenile Diabetes Research Foundation International (JDRF 1-2004-661) (JXS). We thank a number of physicians (David Brown, N Spencer Welch, Paul Davidson, Joseph Johnson, David Robertson, Constance Baldwin, Melissa Carlucci, Mark Rappaport, Robert Schultz and Vijayasudha Gunna) and staff members (Kim English, Jessica Leggett, Katherine Guthrie, Melanie Brown, Deana McFeely, Nellie Jenkins, Tami Kinnersley and Ann Simmonds) for their contribution in sample collection. We are very grateful to all patients and other volunteers who participated in this study.

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Correspondence to J-X She.

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Reddy, M., Wang, H., Liu, S. et al. Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun 12, 208–212 (2011). https://doi.org/10.1038/gene.2010.70

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  • DOI: https://doi.org/10.1038/gene.2010.70

Keywords

  • genetics
  • T1D
  • candidate genes

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