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Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes

Genes & Immunity volume 10, pages S60–S63 (2009)Cite this article

Abstract

Type I diabetes (T1D) results from interactions between environmental exposures and genetic susceptibility leading to immune dysfunction and destruction of the insulin-producing β cells of the pancreas. Vitamin D deficiency is likely to be one of the many environmental factors influencing T1D development and diagnosis, and, hence, the hormone receptor gene, VDR, was examined for association with T1D risk. The Type I Diabetes Genetics Consortium genotyped 38 single nucleotide polymorphisms (SNPs) in 1654 T1D nuclear families (6707 individuals, 3399 affected). Genotypes for 38 SNPs were assigned using the Illumina (ILMN) and Sequenom (SQN) technology. The analysis of data release as of July 2008 is reported for both platforms. No evidence of association of VDR SNPs with T1D at P<0.01 was obtained in the overall sample set, nor in subgroups analyses of the parent-of-origin, sex of offspring and HLA risk once adjusted for multiple testing.

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Acknowledgements

This research uses resources provided by the Type I Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. The work was also supported by grants to JAT from the Wellcome Trust, Juvenile Diabetes Research Foundation and the National Institute for Health Research Biomedical Research Centre award to Cambridge. Genotyping was performed at the Broad Institute Center for Genotyping and Analysis is supported by grant U54 RR020278 from the National Center for Research Resources.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine I, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany

    H Kahles & K Badenhoop

  2. Centre for Diabetes Research, The Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia

    G Morahan

  3. Department of Medical Genetics, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes Inflammation Laboratory, University of Cambridge, Cambridge, UK

    J A Todd

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  1. H Kahles
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Correspondence to K Badenhoop.

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Kahles, H., Morahan, G., Todd, J. et al. Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes Immun 10 (Suppl 1), S60–S63 (2009). https://doi.org/10.1038/gene.2009.93

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