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Topical cyclosporin A in the management of vernal keratoconjunctivitis

Abstract

Purpose To study the efficacy of topical cyclosporin A in children with vernal keratoconjunctivitis in a prospective randomised double-masked trial.

Methods Twenty-four children between 5 and 16 years of age were randomly treated with cyclosporin A (CsA) and placebo (vehicle) and followed up for 4 months.

Results Of the 12 patients given CsA, 11 showed symptomatic improvement by 7 days of starting treatment whereas only 3 patients in the placebo group showed mild symptomatic improvement.

Conclusions Topical cyclosporin is a safe and effective treatment in vernal keratoconjunctivitis.

References

  1. BenEzra D, Peer J, Brodsky M, Cohen E . Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986;101:278–82.

    CAS  Article  Google Scholar 

  2. Caldwell DR, Verin P . Efficacy and safety of lodoxamide 0.1% versus cromolyn sodium 4% in patients with vernal keratoconjunctivitis. Eye 1992;113:632–7.

    CAS  Google Scholar 

  3. Buckley DC, Caldwell DR, Reaves TA . Treatment of vernal keratoconjunctivitis with suprofan, a topical non-steroidal anti-inflammatory agent. Invest Ophthalmol Vis Sci 1993;38:133–40.

    Google Scholar 

  4. Abelson MB, Butrus SI, Weston JH . Aspirin therapy in vernal conjunctivitis. Am J Ophthalmol 1983;95:502.

    CAS  Article  Google Scholar 

  5. Secchi A, Tognon S, Leonardi A . Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 1990;110:641–5.

    CAS  Article  Google Scholar 

  6. Hingorani M, Moodaley L, Calder VL, Buckley RJ, Lightman S . A randomised, placebo-controlled trial of topical cyclosporin A in steroid dependent atopic keratoconjunctivitis. Ophthalmology 1998;105:1715–20.

    CAS  Article  Google Scholar 

  7. Bleik JH, Tabbara KF . Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology 1991;98:1679–84.

    CAS  Article  Google Scholar 

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Correspondence to Viney Gupta.

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Gupta, V., Sahu, P. Topical cyclosporin A in the management of vernal keratoconjunctivitis. Eye 15, 39–41 (2001). https://doi.org/10.1038/eye.2001.10

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  • DOI: https://doi.org/10.1038/eye.2001.10

Keywords

  • India
  • Placebo-controlled trial
  • Topical cyclosporin
  • Vernal keratoconjunctivitis

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