Abstract
Purpose To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects.
Methods Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography.
Results Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 ± 0.04 μg/ml (mean ± SEM) and 1.34 ± 0.14 μg/ml respectively (p<0.0001).
Conclusion Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.
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This study was supported by a grant from the Scientific and Technical Research Council of Turkey (SBAG-COST B1-1477)and contributes to the goals of COST Project B1
Proprietary and financial interest: none
Presented at the annual meeting of the American Academy of Ophthalmology, New Orleans, Louisiana, USA, November 1998
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Çekiç, O., Batman, C., Totan, Y. et al. Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects. Eye 13, 656–659 (1999). https://doi.org/10.1038/eye.1999.178
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DOI: https://doi.org/10.1038/eye.1999.178
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