Abstract
Purpose To identify the modifying factors related to the development of proliferative diabetic retinopathy (PDR).
Methods Thirty-eight eyes of 19 non-insulin-dependent diabetes mellitus (NIDDM) patients with maintained asymmetric PDR were retrospectively reviewed.
Results Five patients with ipsilateral carotid stenoses 90% had PDR. Four patients with high myopia over 6 dioptres and 4 patients with optic atrophy and at least a quadrant defect in the visual field had non-proliferative diabetic retinopathy. Of 6 patients with unilateral asteroid hyalosis, 5 had no posterior vitreous detachment (PVD) and PDR.
Conclusion Two factors reached statistical significance as factors modifying PDR: carotid occlusive disease and PVD. Optic atrophy and high myopia showed trends of being a protective influence.
Similar content being viewed by others
Article PDF
References
Ulbig MRW, Hamilton AMP . Factors influencing the natural course of diabetic retinopathy. Eye 1993;7:242–9.
Valone AJ, McMeel W, Franks EP . Unilateral proliferative diabetic retinopathy. I. Initial findings. Arch Ophthalmol 1981;99:1357–61.
Valone AJ, McMeel W, Franks EP . Unilateral proliferative diabetic retinopathy. II. Clinical course. Arch Ophthalmol 1981;99:1362–6.
Early Treatment Diabetic Retinopathy Study Group. Ophthalmology 1991;98:739–834.
Olk RJ, Lee CM . Classification of diabetic retinopathy. In: Diabetic retinopathy: practical management. JB Lippincott, Philadelphia, 1993:3–21.
Takahashi M, Trempe CL, Maquire K . Vitreoretinal relationship in diabetic retinopathy: a biomicroscopic evaluation. Arch Ophthalmol 1981;99:241–5.
Duker JS, Brown GC, Bosley TM, Colt CA, Reber R . Asymmetric proliferative diabetic retinopathy and carotid artery disease. Ophthalmology 1990;90:869–74.
Browning DJ, Flynn HW, Blankenship GW . Asymmetric retinopathy in patients with diabetes mellitus. Am J Ophthalmol 1988;105:584–9.
Moss SE, Klein R, Klein BEK . Ocular factors in the incidence and progression of diabetic retinopathy. Ophthalmology 1994;101:77–83.
Akiba J, Arzabe CW, Trempe CL . Posterior vitreous detachment and neovascularisation in diabetic retinopathy. Ophthalmology 1990;97:889–91.
Davis MD . Vitreous contraction in proliferative diabetic retinopathy. Arch Ophthalmol 1965;74:741–51.
Jalkh A, Takahashi M, Topilow HW, Trempe CL, McMeel W . Prognostic value of vitreous findings in diabetic retinopathy. Arch Ophthalmol 1982;100:432–4.
Tolentino FL, Lee PF, Schepens CL . Biomicroscopic study of vitreous cavity in diabetic retinopathy. Arch Ophthalmol 1966;75:238–46.
Bergren RL, Brown GC, Duker JS . Prevalence and association of asteroid hyalosis with systemic diseases. Am J Ophthalmol 1991;111:289–93.
Kojima K, Ishigura H, Harada T, Harada K, Awaya S . Clinical and histopathological study of asteroid hyalosis in diabetics. Jpn J Clin Ophthalmol 1987;41:579–83.
Topilow HW, Kenyon KR, Takahashi M . Biomicroscopy, ultrastructure and composition. Arch Ophthalmol 1982;100:964–8.
Wasano T, Hirokawa H, Tagawa H, Trempe CL, Buaney SM . Asteroid hyalosis: posterior vitreous detachment and diabetic retinopathy. Ann Ophthalmol 1987;19:255–8.
Faulborn J, Bowald S . Microproliferations in proliferative diabetic retinopathy and their relationship to the vitreous: corresponding light and electronmicroscopic studies. Graefes Arch Clin Exp Ophthalmol 1985;223:130–8.
Brown GC, Magargal LE, Simeone FA, Goldberg RE, Federman JL, Benson WE . Arterial obstruction and ocular neovascularization. Ophthalmology 1982;89:139–44.
Gay AJ, Rosenbaum AL . Retinal artery pressure in asymmetric diabetic retinopathy. Arch Ophthalmol 1966;75:758–62.
Avetisov ES, Savitskaya NF . Some features of ocular microcirculation in myopia. Ann Ophthalmol 1977;9:1261–4.
Jain IS, Luthra CL, Das T . Diabetic retinopathy and its relation to errors of refraction. Arch Ophthalmol 1967;77:59–65.
D'Amore PA . Mechanisms of retinal and choroidal neovascularization. Invest Ophthalmol Vis Sci 1994;35:3974–9.
Weiter JJ, Zuckerman R . The influence of the photoreceptor-RPE complex on the inner retina: an explanation for the beneficial effects of photocoagulation. Ophthalmology 1980;87:1133–41.
Sebag J, Delori FC . Effects of optic atrophy on retinal blood flow and oxygen saturation in humans. Arch Ophthalmol 1989;107:222–6.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dogru, M., Ino-ue, M., Nakamura, M. et al. Modifying factors related to asymmetric diabetic retinopathy. Eye 12, 929–933 (1998). https://doi.org/10.1038/eye.1998.241
Issue Date:
DOI: https://doi.org/10.1038/eye.1998.241
Keywords
This article is cited by
-
Right versus left eye asymmetry of microvasculature in diabetes revealed by optical coherence tomography angiography
Scientific Reports (2023)
-
Axial myopia, a protective factor for diabetic retinopathy-role of vascular endothelial growth factor
Scientific Reports (2022)
-
Male sex increases the risk of diabetic retinopathy in an urban safety-net hospital population without impacting the relationship between axial length and retinopathy
Scientific Reports (2022)
-
Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography
BMC Ophthalmology (2020)
-
Static characteristics and dynamic functionality of retinal vessels in longer eyes with or without pathologic myopia
Graefe's Archive for Clinical and Experimental Ophthalmology (2016)
