Abstract
In the von Szily mouse model, intracameral inoculation of herpes simplex virus type-1 (HSV-1) results in inflammation of the ipsilateral anterior segment with relative chorioretinal sparing and destructive contralateral chorioretinitis. We studied the effect of the systemic antiviral agent acyclovir (ACV) and anti-HSV-1 antibody therapy in this model. Contralateral chorioretinitis developed in none of the 18 mice receiving ACV from post-inoculation day (pid) 1 (p<.0001), in 6 of 10 (60%) mice when treatment was delayed until pid 7 (p= 0.40) and in 14 of 18 (77%) controls. Contralateral disease developed in 8 of 16 (50%) mice that received anti-HSV-1 antibody from pid 1 (p= 0.02), in 13 of 16 (81%) treated from pid 5 (p= 0.64), in 7 of 8 (87.5%) treated from pid 7 (p= 1.0) and in 17 of 20 (85%) controls. We conclude that early treatment with ACV or anti-HSV-1 antibody reduces the incidence of contralateral chorioretinitis in mice.
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Merchant, A., Fletcher, J., Medina, C. et al. Pharmacomanipulation of HSV-1 induced chorioretinitis in mice. Eye 11, 504–508 (1997). https://doi.org/10.1038/eye.1997.135
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DOI: https://doi.org/10.1038/eye.1997.135