Opportunities for studying growth, degeneration and repair in the central nervous system have altered over the last decade with the development of techniques for cul-turing neurones and glia and the availability of immun-ological or molecular markers that identify separate lineages and their progeny. Much pioneering work has been carried out in the rodent optic nerve but the principles that emerge are representative for other parts of the nervous system; development of neurones and glia may differ substantially in rats and man, so that assumptions must be made in extrapolating from properties of the rat optic nerve to diseases of the human central nervous system.
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Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study
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