Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Autonomic function in Holmes Adie Syndrome

Eye volume 4, pages 607–612 (1990)Cite this article

Abstract

Autonomic function was studied in a group of 11 patients with Holmes Adie Syndrome. Autonomie function was assessed by the measurement of cardiovascular reflexes. Heart rate responses to respiration, valsalva manoeuvre and standing were studied. The change in systolic blood pressure on moving from the lying to the standing position was measured. Abnormalities of parasympathetic function were found in three patients, compared with matched controls. Autonomie dysfunction in Holmes Adie Syndrome may be more widespread than previously suspected.

Download PDF

References

  1. Holmes G : Partial iridoplegia associated with symptoms of other diseases in the nervous system. Trans. Ophthalmol. Soc. UK 1931, 51: 209–28.

    Google Scholar 

  2. Adie WJ : Tonic pupils and absent tendon reflexes, a benign disorder sui generis: its complete and incomplete forms. Brain 1932, 55: 98–113.

    Article  Google Scholar 

  3. Loewenfeld IE and Thompson HS : The tonic pupil: A re-evaluation. Am. J. Ophthalmol. 1967, 63: 46–87.

    CAS  Article  Google Scholar 

  4. Harriman DGF and Garland H : The pathology of Adies Syndrome. Brain 1968, 91: 401–18.

    CAS  Article  Google Scholar 

  5. Bourgon P, Pilley SFJ, Thompson HS : Cholinergic supersensitivity of the iris sphincter in Adies tonic pupil. Am. J. Ophthalmol. 1978, 85: 373–7.

    CAS  Article  Google Scholar 

  6. Selhorst JB, Madge G, Ghatol NR, Richmond VA : The neuropathology of the Holmes Adie Syndrome. Ann Neurol. 1984, 16: 138.

    Google Scholar 

  7. Ewing DJ and Clarke BF : Diagnosis and management of diabetic autonomie neuropathy. Br. Med. J. 1982, 285: 916–18.

    CAS  Article  Google Scholar 

  8. Mitchell RB, Sharief BS : Cahill SJ, Jenkins JG, McClure BG : Proceedings of the IEEE Montech 1987 Conference on Biomedical Technologies, Montreal 1987: 167–170.

  9. Thompson HS : Topics in Neurophthalmology. Baltimore, Williams & Wilkins Co. 1979: 95–113.

  10. Abbruzzese G, Abbruzzese M, Fauale E, Ratto S : Tonic vibration reflex in Holmes Adie Syndrome: An electrophysiological study. J. Neurol. Neurosurg. Psychia 1979, 42: 943–47.

    CAS  Article  Google Scholar 

  11. Ross AT : Progressive sudomotor denervation. Neurology 1958, 8: 809–17.

    CAS  Article  Google Scholar 

  12. Bacon PJ and Smith S : Adie's Syndrome: Ophthalmic Dialogue 1988 No. 3.

  13. Ewing DJ, Campbell IW, Clarke BF : The natural history of diabetic autonomie neuropathy. Q. J. Med. 1980, 49: 95–108.

    CAS  PubMed  Google Scholar 

  14. Wheeler T and Watkins PJ : Cardiac denervation in diabetes. Br. Med. J. 1973, 4: 584–6.

    CAS  Article  Google Scholar 

  15. Wieling W, Van Brederode JFM, De Rijk LG, Borst C and Dunning AJ : Reflex control of heart rate in normal subjects in relation to age: a database for cardiac vagal neuropathy. Diabetologia 1982, 22: 163–66.

    CAS  Article  Google Scholar 

  16. Smith SA : Reduced sinus arrhythamia in diabetic autonomic neuropathy: diagnostic value of an age-related normal range. Br. Med. J. 1982, 285: 1599–601.

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Ophthalmology, Professorial Unit, Royal Victoria Hospital, Belfast

    M Hope-Ross, T A S Buchanan & D B Archer

  2. Department of Physiology, The Queen's University of Belfast, Belfast

    J A Allen

Authors
  1. M Hope-Ross
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T A S Buchanan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D B Archer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J A Allen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hope-Ross, M., Buchanan, T., Archer, D. et al. Autonomic function in Holmes Adie Syndrome. Eye 4, 607–612 (1990). https://doi.org/10.1038/eye.1990.85

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/eye.1990.85

Further reading

Search

Advanced search

Quick links