Abstract
The superficial circulations of the anterior segment of the human eye have been studied by the following techniques: photographic and video low-dose fluorescein angiography, video-microscopy using red-free light and stereoscopic colour photography. The results are combined to give a dynamic description of the limbal circulation, including its arterial supply and venous drainage.
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Friend J : Physiology of the cornea: metabolism and biochemistry. In Smolin G, Thoft RA eds. The cornea: Boston, Toronto: Little, Brown & Co. 1983: 17–31.
Shapiro MS, Friend J, Thoft RA : Corneal re-epi-thelialisation from the conjunctiva. Invest Ophthalmol Vis Sci 1981, 21: 135–42.
Kinoshita S, Friend J, Thoft RA : Sex chromatin of donor corneal epithelium in rabbits. Invest Ophthalmol Vis Sci 1981, 21: 434–41.
Grierson I : Alterations in the outflow system in chronic simple glaucoma. In McAllister JA, Wilson RP eds. Glaucoma: London: Butterworths 1986: 1–29.
Iwamoto T and Smelser GK : Electron microscopic studies of corneal capillaries. Invest Ophthalmol Vis Sci 1965, 4: 815–34.
Ausprunk DH, Boudreau CL, Nelson DA : Proteoglycans in the microvasculature I: histochemical localisation in microvessels of the rabbit eye. Am J Pathol 1981, 103: 353–66.
Ausprunk DH, Boudreau CL, Nelson DA : Proteoglycans in the microvasculature II: histochemical localisation in proliferating capillaries of the rabbit cornea. Am J Pathol 1981, 103: 367–75.
Eisenstein R, Goren SB, Shumacher B, Choromokos E : The inhibition of corneal vascularization with aortic extracts in rabbits. Am J Ophthalmol 1979, 88: 1005–12.
Eisenstein R, Meineke C, Shumacher B, Kuettner KE : Regulators in aorta (abstract) Am J Pathol 1977, 86: 32a–3a.
Ashton N and Cook C : Mechanisms of corneal vascularisation. Br J Ophthalmol 1953, 37: 193–209.
Folkman JE, Marier E, Abernathy C, Williams G : Isolation of a tumour factor responsible for angiogenesis. J Exp Med 1971, 133: 275–88.
Gimbrone MA, Cotran RS, Leapman SB, Folkman J : Tumour growth and neovascularisation: an experimental model using the rabbit cornea. J Natl Cancer Inst 1974, 52: 413–27.
Gospodarowicz D, Bialecki H, Thakral TK : The angiogenic activity of fibroblast and epidermal growth factor. Exp Eye Res 1979, 28: 501–14.
Zauberman H, Michaelson IC, Bergman F : Stimulation of neovascularisation of the cornea by biogenic amines. Exp Eye Res 1969, 8: 77–83.
Ben Ezra D : Neovasculogenic ability of prostaglandins, growth factors and synthetic chemoattractants. Am J Ophthalmol 1978, 86: 455–61.
Ziehe M, Jones J, Gullino PM : Role of prostaglandin El and copper in angiogenesis. J Natl Cancer Inst 1982, 69: 475–82.
Imre G : Studies on the mechanisms of retinal neovascularisation. Br J Ophthalmol 1964, 48: 75–82.
Bessey DA and Wolbach SB : Vascularisation of the cornea of the rat in riboflavin deficiency, with a note on corneal vascularisation in vit. A deficiency. J Exp Med 1969, 69: 1–12.
Epstein RJ and Hughes WF : Lymphocyte-induced corneal neovascularisation: a morphologic assessment. Invest Ophthalmol Vis Sci 1981, 21: 87–94.
Fromer CH and Klintworth GK : An evaluation of the leukocytes in the pathogenesis of experimentally induced corneal vascularisation III: studies related to the vasoproliferative capability of polymorphonuclear leukocytes and lymphocytes. Am J Pathol 1976, 82: 157–67.
Sholley MM, Gimbrone MA, Cotran RS : The effects of leucocyte depletion on corneal neovascularisation. Lab Invest 1978, 38: 32–40.
Eliason JA : Leucocytes and experimental corneal vascularisation. Invest Ophthalmol Vis Sci 1978, 17: 1087–95.
Leber T : Die Cirkulations— und Ernahrungsverhaltnisse des Auges. (Graefe-Saemisch Handbuch der Gesamten Augenheilkunde.) Leipzig: Engelmann, 1903, 2: ch.1.
Morrison JC and Van Buskirk EM : Anterior collateral circulation in the primate eye. Ophthalmology 1983, 90: 707–15.
Ashton N and Smith R : Anatomical study of Schlemm's canal and aqueous veins by means of Neoprene casts. Part III: arterial relations of Schlemm's canal Br J Ophthalmol 1953, 37: 577–86.
Virdi PS and Hayreh SS : Anterior segment ischemia after recession of various recti: an experimental study. Ophthalmology 1987, 94: 1258–71.
Wilcox LM, Keough EM, Connolly RJ, Hotte CE : The contribution of blood flow by the anterior ciliary arteries to the anterior segment in the primate eye. Exp Eye Res 1980, 30: 167–74.
Ikegami M : Fluorescein angiography of the anterior ocular segment. Part I: Hemodynamics in the anterior ciliary vessels. Ada Soc Ophthalmol Jpn 1974, 78: 39–53.
Talusan ED and Schwartz B : Fluorescein angiography: demonstration of flow pattern in anterior ciliary arteries. Arch Ophthalmol 1981, 99: 1074–80.
Watson PG and Bovey E : Anterior segment fluorescein angiography in the diagnosis of scleral inflammation. Ophthalmology 1985, 92: 1–11.
Amalric P, Rebiere P, Jourdes JC : Nouvelles indications de l'angiographie fluoresceinique du segment antèrieur de l'oeil. Ann Oculist 1971, 204: 455–68.
Bron AJ and Easty DL : Fluorescein angiography of the globe and anterior segment. Trans Ophthalmol Soc UK 1970, 90: 339–67.
Kiss F : Der Blutkreislauf der Auges. Ophthalmologica 1943, 106: 225–50.
Hayreh SS and Scott WE : Fluorescien iris angiography. II Disturbances in iris circulation following strabismus operation on the various recti. Arch Ophthalmol 1978, 96: 1390–400.
Meyer PAR : Patterns of blood flow in episcleral vessels studied by low-dose fluorescein videoangiography. Eye 1988, 2: 533–46.
Ashton N : Anatomical study of Schlemm's canal and aqueous veins by means of Neoprene casts. Br J Ophthalmol 1951, 35: 291–303.
Ashton N : Anatomical study of Schlemm's canal and aqueous veins by means of Neoprene casts. Part II: aqueous veins. Br J Ophthalmol 1952, 36: 265–7.
Duke-Elder S and Wybar KC : Blood vessels and nerves of the eye. In Duke-Elder S, ed. System of Ophthalmology: London: Kimpton, 1961; 2: chapter 4.
Hogan MJ, Alvarad JA, Weddell JE : Histology of the human eye. Philadelphia, London, Toronto: WB Saunders Co, 1971: 119–26.
Meyer PAR and Watson PG : Low dose fluorescein angiography of the conjunctiva and episclera. Br J Ophthalmol 1987, 71: 2–10.
Korber N, Jung F, Kiesewetter H, Wolf S, Prunte C, Reim M : Microcircualtion in the conjunctival capillaries of healthy and hypertensive patients. Klin Wochenschr 1986, 64: 953–5.
Novotny HR and Alvis DL : A method for photographing fluorescence in circulating blood in the human retina. Circulation 1961, 24: 82–6.
Brubaker FR, Penniston JT, Grotte DA, Nagataki S : Measurement of fluorescein binding in human plasma using fluorescence polarisation. Arch Ophthalmol 1982, 100: 625–30.
Palestine AG and Brubaker RF : Plasma binding of fluorescein in normal subjects and in diabetic patients. Arch Ophthalmol 1982, 100: 1160–1.
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Meyer, P. The circulation of the human limbus. Eye 3, 121–127 (1989). https://doi.org/10.1038/eye.1989.19
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DOI: https://doi.org/10.1038/eye.1989.19
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