Abstract
The ocular findings in a series of patients with dystrophic epidermolysis bullosa are presented. An immunopathological technique using monclonal antibodies for examining components of the epithelial basement membrane of the conjunctiva is described and the results obtained on a conjunctival biopsy from a patient with dystrophic epidermolysis bullosa are presented.
Article PDF
References
McDonnell PJ and Spalton DJ : The ocular signs and complications of epidermolysis bullosa. J Roy Soc Med (in press).
Eady RAJ, Tidman MJ, Heagerty AHM, Kennedy AR : Approaches to the study of epidermolysis bullosa. In Honigsmann H ed. Current Problems in Dermatology. Basel: S Karger. 1987, 17: 127–41.
Leigh IM, Purkis PE, Bruckner Tiderman L : LH 7:2 monoclonal antibody detects type VII collagen in the basement membrane of ectodermally derived epithelia including skin. Epithelia 1988, 1: 17–29.
Leigh IM, Eady RAJ, Heagerty AHM, Purkis PE, Whitehead PA, Burgeson RE : Type VII COllagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic bullosa. J Invest Dermatol 1988, 90: 639–42.
Heagerty AHM, Kennedy AR, Leigh IM, Purkis PE, Eady RAJ : Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis. BrJ Dermatol 1986, 115: 125–31.
Duke—Elder S : Systems of Ophthalmology. London: Henry Kimpton. 1965, 8: 524–7.
Gedde—Dahl T : Epidermolysis bullosa: a clinical, genetic and epidemiological study. London: The John Hopkins Press. 1971, 64–94.
Gans LA : Eye lesions of epidermolysis bullosa. Arch Dermatol 1988, 124: 762–4.
Destro M, Wallow IHL, Brightbill FS : Recessive dystrophic epidermolysis bullosa. Arch Ophthalmol 1987, 105: 1248–52.
Wright P : Cicatrising conjunctivitis. Trans Ophthalmol Soc UK 1986, 105: 1–17.
Forgacs J and Franceschetti A : Histologic aspect of corneal changes; due to hereditary, metabolic, and cutaneous affections. Am J Ophthalmol 1959, 47: 191–202.
Pearson RW : Studies on the pathogenesis of epidermolysis bullosa. J Invest Dermatol 1962, 39: 551–75.
Fine JD, Brcathnach S, Hintner H, Katz S : KF—1 monoclonal antibody defines a specific basement membrane antigen defect in dystrophic forms of epidermolysis bullosa. J Invest Dermatol 1984, 82: 35–8.
Goldsmith LA and Briggaman RA : Monoclonal antibodies to anchoring fibrils for the diagnosis of epidermolysis bullosa. J Invest Dermato1 1983, 81: 464–6.
Heagerty AHM, Kennedy AR, Leigh IM, Eady RAJ : LH 7:2 monoclonal antibody defines a common dermo—epidermal junction defect in recessive forms of dystrophic epidermolysis bullosa (abstract). J Invest Dermatol 1985, 84: 448.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McDonnell, P., Schofield, O., Spalton, D. et al. The eye in dystrophic epidermolysis bullosa: Clinical and immunopathological findings. Eye 3, 79–83 (1989). https://doi.org/10.1038/eye.1989.11
Issue Date:
DOI: https://doi.org/10.1038/eye.1989.11