Abstract
Clinically scarred and neovascularised corneas observed after zosteriform spread of herpes simplex virus (HSV) to the eye of the mouse were found to contain chronic inflammatory cells with a loose retrocorneal membrane. Goblet cells were found in the corneal epithelium.
The trigeminal ganglia of such animals were latently infected with HSV. Whereas HSV was not isolated from eye-washings of diseased eyes, it was isolated from some anterior segments after culture in vitro for up to 13 days. When anterior segments were halved sagittally, HSV could not be isolated from the halves assayed immediately, whereas it was isolated from some of the other halves after organ culture. The possibility of ocular latency is discussed.
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Tullo AB : Herpes simplex keratitis: latent and recurrent infection. In Easty DL and Smolin G, eds. External Eye Disease, London: Butterworths 1985; 133–153.
O'Day DM and Jones BR : Herpes simplex keratitis. In Duane TD and Jaeger EA, eds. Clinical Ophthalmology, Vol. 4, Cambridge: Harper and Row 1985; 1–20.
Dawson C, Togni B, Moore TE : Structural changes in chronic herpetic keratitis. Arch Ophthalmol 1968, 79: 740–7.
Metcalf JF and Kaufman HE : Herpetic stromal keratitis—evidence for cell-mediated immuno-pathogenesis. Am J Ophthalmol 1976, 82: 827–34.
Jones BR, Falcon MG, Williams HP, Coster DJ : Symposium on Herpes Simplex Eye Disease: Objectives of Therapy of Herpetic Eye Disease. Trans Ophthalmol Soc UK 1977, 97: 305–13.
Meyers-Elliott RH, Pettitth, Maxwell A : Viral antigens in the immune ring of herpes simplex stromal keratitis. Arch Ophthalmol 1980, 98: 897–904.
Ahonen R, Vannas A, Makitie J : Virus particles and leukocytes in herpes simplex keratitis. Cornea 1984, 3: 43–50.
Shimeld C, Tullo AB, Easty DL, Thomsitt J : Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. Br J Ophthalmol 1982, 66: 643–7.
Tullo AB, Easty DL, Shimeld C, Stirling PE, Darville JM : Isolation of herpes simplex virus from corneal discs of patients with chronic stromal keratitis. Trans Ophthalmol Soc UK 1985, 104: 159–65.
Coupes D, Klapper PE, Cleator GM, Bailey AS, Tullo AB : Herpesvirus simplex in chronic human stromal keratitis. Curr Eye Res 1986, 5: 735–8.
Cook SD, Aitken DA, Loeffler KU, Brown SM : Herpes simplex virus in the cornea: an ultrastruc-tural study on viral reactivation. Trans Ophthalmol Soc UK 1986, 105: 634–41.
Openshaw H : Latency of herpes simplex virus in ocular tissue of mice. Infection and Immunity 1983, 39: 960–2.
Shimeld C, Lewkowicz-Moss SJ, Lipworth KM, Hill TJ, Blyth WA, Easty DL : Antigens of herpes simplex virus in whole corneal epithelial sheets from mice. Arch Ophthalmol 1986, 104: 1830–4.
Claoue CMP, Hodges TJ, Hill TJ, Blyth WA, Easty DL : The Histology of the Eye after Zosteriform Spread of Herpes Simplex virus in the Mouse. Br J Exp Path (in press).
Claoue CMP : A New Look at Experimental Herpes Simplex Eye Disease; Preliminary Results of Clinical Disease in the NIH Mouse after Zosteriform Spread. Trans Ophthalmol Soc UK 1986, 105: 401–3.
Tullo AB : Mechanisms of Latent and Recurrent Ocular Infection with Herpes Simplex Virus. MD Thesis, University of Bristol, 1982.
Hill TJ, Field HJ, Blyth WA : Acute and recurrent infection with herpes simplex virus in the mouse: A model for studying latency and recurrent disease. J Gen Virol 1975, 28: 341–53.
Easty DL : Viral Disease of the Eye, London, Lloyd-Luke, 1985.
Claoué CMP, Hill TJ, Blyth WA, Easty DL : Clinical Findings after Zosteriform Spread of Herpes Simplex Virus to the Eye of the Mouse. Curr Eye Res 1987. 6: 281–6.
Sery TW : Random Occurrence of Herpetic Disci-form Keratitis in Rabbits. Am J Ophthalmol 1959, 48: 57–71.
Kimura SJ : Herpes simplex uveitis: a clinical and experimental study. Trans Am Ophthalmol Soc 1962, 60: 440–70.
Hogan MJ, Kimura SJ, Thygeson P : Pathology of herpes simplex kerato-iritis. Am J Ophthalmol 1964, 57: 551–64.
Teitelbaum CS, Streelen BW, Dawson CR : Histo-pathology of herpes simplex keratouveitis. Invest Ophthalmol Vis Sci 1986, 27: (3), ARVO supplement p 47.
Weiner JM, Carroll N, Robertson If : The Granu-lomatous reaction in herpetic stromal keratitis: immunohistochemical and ultrastructural findings. Aus and NZ J Ophthalmol 1985, 13: 365–72.
Hill TJ : Herpes simplex virus latency. In B Roizman, ed. The Herpesviruses Vol 3, London, Plenum Press, 1985, 175–240.
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Presented at the Annual Congress of the Ophthalmological Society of the United Kingdom, April 1987.
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Claoué, C., Blyth, W., Hill, T. et al. Does herpes simplex virus establish latency in the eye of the mouse?. Eye 1, 525–528 (1987). https://doi.org/10.1038/eye.1987.79
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DOI: https://doi.org/10.1038/eye.1987.79