Table 1 MSC and CFU-F concentrations and frequency derived from adult and near-fetal tissues

From: Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

Human tissue source Native CFU-F concentration range per ml of fluid/tissue MSC frequency range (CFU-F/10 6 nucleated cells) References
Bone marrow aspirate 109–664a 10–83 91, 183, 184, 185, 186, 187
Adipose/lipoaspirate 2058–9650 205–51 000 98, 184, 188, 189, 190
Dermis Not reported 74 000–157 000 89
Umbilical cord blood 0.06 0–0.02 184, 185, 191, 192
Peripheral blood 0 0–2b 185, 192, 193
Synovial fluid 4–14 2–250 92, 194
Amniotic fluid 3 9.2 195
  1. aBased on average of 8 × 106 nucleated cells per ml bone marrow aspirate.183
  2. bOccurance of CFU-F in peripheral blood requires systemic treatment with GCSF.