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Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays

Experimental & Molecular Medicine volume 37, pages 1–10 (2005)Cite this article

Abstract

Proteomics is one of the most important issues in the post-genomic area, because it can greatly contribute to identifying protein biomarkers for disease diagnosis and drug screening. Protein array is a key technology for proteome researches and has been analyzed by various methods including fluorescence, mass spectrometry, atomic force microscopy and surface plasmon resonance (SPR). SPR biosensor is a promising technology in proteomics, since it has various advantages including real-time measurement of biomolecular interactions without labeling and the simple optical system for the device. SPR biosensors have a strong potential for analyzing proteomes by SPR imaging and SPR spectroscopic imaging, even though the challenge is to produce proteins on a proteomic scale.

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  1. Department of Molecular and Cellular Biochemistry, Nano-bio Sensor Research Center, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, South Korea

    Jong Seol Yuk

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  1. Jong Seol Yuk
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  2. Kwon-Soo Ha
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cite this article

Yuk, J., Ha, KS. Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays. Exp Mol Med 37, 1–10 (2005). https://doi.org/10.1038/emm.2005.1

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  • DOI: https://doi.org/10.1038/emm.2005.1

Keywords

  • biosensing techniques
  • microscopy
  • atomic force
  • protein array analysis
  • proteome
  • proteomics
  • surface plasmon resonance

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