Table 1 Top 10 genes from the analysis of rvTDT with 320 and subsequently with the subset of 286 European ancestry trios

From: Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data

Test Gene Number of SNVs a Uncorrected P-value
Analysis of rvTDT with 320 trios ABCA13 52 1.17E−05
  CENPO 4 0.00236
  DST 51 0.00297
  IPPK 5 0.00198
  PCF11 10 0.00032
  SCAPER 5 0.00137
  SLC46A3 6 0.00185
  STEAP4 4 0.00291
  TRAF3IP1 7 0.00292
  ZNF878 7 0.00252
Analysis of rvTDT with 286 trios ABCA13 52 0.00025
  SCAPER 5 0.00046
  ANKZF1 11 0.00079
  DST 51 0.00123
  TRAF3IP1 7 0.00172
  STEAP4 4 0.00247
  SBSN 12 0.00295
  OR2B2 5 0.00298
  SAP130 8 0.00326
  SCARF1 11 0.00344
  1. P-value is based on the linear combination test with population controls. Adjusted α correcting for the number of genes is P<2.81 × 10−6.
  2. aRepresenting the number of qualifying variants found in this gene across all families.
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