Facial features and pedigree of family with NONO variant. (a) Frontal view. (b) Side view. (c) Pedigree of family showing the segregation of NONO variant. Wild-type NONO allele is indicated by plus sign. Filled symbols indicate affected individuals. Y sign indicates Y chromosome. (d) Schematic representation of NONO. Variants characterized in this work and in the study by Mircsof et al2 are annotated above the appropriate exons (exons are numbered like in the study by Mircsof et al)2.