Brain MR imaging of patient with NONO variant. (a, b) MR imaging at age 2 years, (a) sagittal T1-weighted demonstrates macrocephaly and hypoplastic corpus callosum with underdeveloped splenium. (b) Axial T2-weighted shows cava septi pellucidi, cava vergae, and cava veli interpositi. (c, d) MR imaging at age 16 years, (c) sagittal T1-weighted demonstrates thick calvarium, short and hypoplastic corpus callosum. (d) Axial T1-weighted shows normal cerebellum. T1- and T2-weighted are the important technical terms for the imaging analysis.