Figure 2 | European Journal of Human Genetics

Figure 2

From: Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes

Figure 2

Power to detect association (at genome-wide significance, P<5 × 10−8) of a binary phenotype with a causal SNP, in the presence of population stratification (cases and controls ascertained from sub-populations (A and B), using alternative meta-analysis strategies for summary statistics obtained from linear regression models with random effects for the GRM (Table 1). Results are presented as a function of the probability that a case is ascertained from sub-population A, for a causal SNP with allelic OR of 1.15 for the binary phenotype and for variable extent of case–control imbalance (defined in Table 2).

Back to article page