Table 1 p.Tyr179Cys and p.Gly396Asp allele frequencies in MAP and CRC patients and in controls from different populations

From: MUTYH-associated polyposis (MAP): evidence for the origin of the common European mutations p.Tyr179Cys and p.Gly396Asp by founder events

Study group Country or population N. subjects tested p.Tyr179Cys allele frequency (%) p.Gly396Asp allele frequency (%) References
Classical or attenuated polyposis cases Germany 544 5.5 4.5 6, 7
  Italy 110 9.2 4.1 8, 9, 10
  Sweden 15 16.8 3.2 3
  Netherlands 170 12 4.7 11
  Czech Republic 86 1.7 1.7 12, 13
  France 61 9 7.3 14, 15
  Switzerland 79 3.8 2.6 16
  Portugal 160 10.3 8.4 17, 18
  UK-Denmark-Finland 258 5.4 3.3 4, 19
  Spain 254 2.2 3.7 20, 21
  Canada (European origin) 20 9.9 5.1 22
  North America 188 10.9 5.8 23, 24
  Brazil 30 5 6.6 25
  Australia 120 7.9 4 26
  Taiwan 66 0 0 27
  South Korea 62 0 0 28
  Japan 56 0 0 29, 30
  Indians/Pakistani 6 0 0 19, 31
  Singapore 3 0 0 32
  Morocco 13 7.7 15.4 33
  Tunisia 10 0 5 34
Unselected CRC cases UK (white) 9268 0.5 0.9 35
  Spain 1116 0.2 0.3 36
  Canada-Australia-USA 3811 0.4 1.2 37
  North America 444 0.9 0.7 24
  Morocco 49 0 0 33
  Tunisia 83 0.6 1.1 34
  Arabs 327 0 0.2 38
  Moroccan Jews 232 0.4 3.4 38
  Ashkenazi Jews 189 0 0 38
Controls Germany 116 0.4 0.4 6
  Italy 247 0.2 0 39
  Sweden 466 0.2 0.1 40
  Czech Republic 100 0 0 12
  France 1121 0.2 0.7 41
  UK (white) 5064 0.3 0.7 35, 42
  UK 461 0.2 0.1 4, 43
  Scotland 2649 0.3 0.6 44, 45
  Finland 424 0 0 46
  Spain 1231 0.04 1.1 36, 47
  Canada-Australia-USA 2802 0.2 0.6 37
  North America 313 0.3 0.3 24
  Canada 2067 0.2 0.6 22, 48
  Caucasian/Hispanic (US) 32 0 1.6 49
  Caucasian (US) 360 0.3 0.6 49
  Australia 478 0.4 0.1 50
  Chinaa 101 0 0 51
  Arabs 304 0 0 38
  Moroccans 400 0.1 0.4 52
  Sephardi Moroccan Jews 541 0.4 1.8 53
  Jews (US) 450 0 0 49
  1. Abbreviation: CRC, colorectal cancer.
  2. The study population was represented by patients with gastric carcinoma.