Table 3: Replication of suggestive associations identified in Silesian Hypertension Study in CoLaus cohort

From: FGF21 signalling pathway and metabolic traits – genetic association analysis

TraitGeneSNPMAMAFRisk alleleβ-coefficientSEP-value
LDL-CFGFR1rs7012413T0.30T0.0180.0210.37
  rs4733946T0.08T0.0270.0370.48
 FGFR2rs2071616T0.31T0.0920.0350.009
 KLBrs7670309A0.42G0.0240.0190.21
BMIKLBrs2608819T0.13T0.0140.1280.91
  1. Abbreviations: BMI, body mass index; LDL-C, LDL-cholesterol; MA, minor allele; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.
  2. β-coefficient, estimated quantitative effect of each SNP minor allele copy on a metabolic phenotype (adjusted for age, age2 and sex).