Figure 1

From: FGF21 signalling pathway and metabolic traits – genetic association analysis

Figure 1

Fibroblast growth factor receptor 2 gene (FGFR2)-association and evolutionary analysis. (a) Upper: −log transformed probability values from the analysis of association between FGFR2 and LDL-C in Silesian Hypertension Study; lower: linkage disequilibrium (LD) map (r2 coefficient-based) of FGFR2 SNPs. Note: dark-red squares indicate high r2 and therefore high LD, white squares indicate r2=0 and no LD. (b) FGFR2 binds FGF21 in the presence of KLB (a transmembrane cofactor); B-binding. (c) Sequence alignment of region containing SNP rs2071616 in FGFR2 across 15 mammalian species, position of rs2071616 is marked in red. (d) Evolutionary conservation of region in FGFR2 surrounding SNP rs2071616, the position of which is marked by the arrow.