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The mystery of longevity in Cilento: a mix of a good dose of genetic predisposition and a balanced diet based on the Mediterranean model

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References

  1. Contaldo F, Scalfi L, Pasanisi F . Ancel keys centenary and the definition of healthy diet. Clin Nutr 2004; 23: 435–436.

    Article  Google Scholar 

  2. Di Daniele N, Noce A, Vidiri MF, Moriconi E, Marrone G, Annicchiarico-Petruzzelli M et al. Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget 2017; 8: 8947–8979.

    Article  Google Scholar 

  3. Grosso G, Buscemi S, Galvano F, Mistretta A, Marventano S, La Vela V et al. Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects. BMC Surg 2013; 13 (Suppl 2), S14.

    Article  Google Scholar 

  4. Spinetti G, Sangalli E, Specchia C, Villa F, Spinelli C, Pipolo R et al. The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. Aging (Albany NY) 2017; 9: 370–380.

    Article  CAS  Google Scholar 

  5. Villa F, Malovini A, Carrizzo A, Spinelli C, Ferrario A, Caciag A et al. Serum BPIFB4 levels classify health status in long-living individuals. Immun Ageing 2015; 12: 27.

    Article  Google Scholar 

  6. Liyanage T, Ninomiya T, Wang A, Neal B, Jun M, Wong MG et al. Effects of the Mediterranean diet on cardiovascular outcomes-a systematic review and meta-analysis. PLoS One 2016; 11: e0159252.

    Article  Google Scholar 

  7. Taormina G, Mirisola MG . Longevity: epigenetic and biomolecular aspects. Biomol Concepts 2015; 6: 105–117.

    Article  CAS  Google Scholar 

  8. Hardy TM, Tollefsbol TO . Epigenetic diet: impact on the epigenome and cancer. Epigenomics 2011; 3: 503–518.

    Article  CAS  Google Scholar 

  9. Tejada S, Pinya S, Del Mar Bibiloni M, Tur JA, Pons A, Sureda A . Cardioprotective effects of the polyphenol hydroxytyrosol from olive oil. Curr Drug Targets 2016, e-pub ahead of print 5 October 2016.

  10. Thiel G, Rössler OG . Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors. Pharmacol Res 2017; 117: 166–176.

    Article  CAS  Google Scholar 

  11. Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G . Mediterranean diet, telomere maintenance and health status among elderly. PLoS One 2013; 8: e62781.

    Article  CAS  Google Scholar 

  12. Buettner D . The Blue Zones: Lessons for Living Longer from the People who’ve Lived the Longest. National Geographic Books: Washington, DC, USA, 2009.

    Google Scholar 

Download references

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Bifulco, M., Pisanti, S. The mystery of longevity in Cilento: a mix of a good dose of genetic predisposition and a balanced diet based on the Mediterranean model. Eur J Clin Nutr 71, 1020–1021 (2017). https://doi.org/10.1038/ejcn.2017.91

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