Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials

Abstract

Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin’s effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations. A systematic search was performed in several databases including SCOPUS, PubMed–Medline and Google Scholar until 16 June 2016. We used a random-effects model in combination with weight mean difference (WMD) and 95% confidence intervals (CI) for data analysis. Standard methods were used for the assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias. The meta-analysis of seven RCTs (10 treatment arms) showed a significant reduction of circulating CRP levels (WMD: −0.33 mg/l; 95% CI: −0.50 to −0.15; P<0.001) following quercetin supplementation. In the subgroup analysis, a significant reducing effect was observed in trials with 500 mg/day dosage (WMD: −0.34 mg/l; 95% CI: −0.52, −0.16; P0.001) and in those with CRP <3 mg/l (WMD: −0.34 mg/l; 95% CI: −0.51, −0.18; P0.001). In meta-regression, there was no association between changes in CRP concentrations, dose of supplementation and CRP baseline values. Our findings showed a significant effect of quercetin supplementation on the C-reactive protein—especially at doses above 500 mg/day and in patients with CRP <3 mg/l.

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Correspondence to Z Mazloom.

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MMS and ZM conceived the study. MMS carried out the literature search and wrote the manuscript. SSH and DF carried out data extraction and independent reviewing. MMS and ZM assessed the quality of included studies. MMS and MGH performed data analysis and interpretation. ZM revised the manuscript. The manuscript has been read and approved by all authors.

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Mohammadi-Sartang, M., Mazloom, Z., Sherafatmanesh, S. et al. Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr 71, 1033–1039 (2017). https://doi.org/10.1038/ejcn.2017.55

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