Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Enteral versus parenteral nutrition in critically ill patients with severe pancreatitis: a meta-analysis

European Journal of Clinical Nutrition volume 72, pages 66–68 (2018)Cite this article

Subjects

Abstract

Whether enteral nutrition (EN) is superior to parenteral nutrition (PN) in critically ill patients with severe acute pancreatitis remains unknown. The objective of this meta-analysis was to assess the effects of EN versus PN on clinical outcomes in a subgroup of pancreatitis patients. Relevant randomized controlled trials (RCTs) were searched in Scopus, PubMed and Web of Science from inception to August 2016. Ultimately, five RCTs including 348 patients were enrolled in this analysis. Compared with PN, EN was associated with a significant reduction in overall mortality (risk ratio (RR)=0.36, 95% confidence interval (CI) 0.20–0.65, P=0.001) and the rate of multiple organ failure (RR=0.39, 95% CI 0.21–0.73, P=0.003). EN should be recommended as the preferred route of nutrition for critically ill patients with severe acute pancreatitis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Quan HM, Wang XP, Guo CY . A meta-analysis of enteral nutrition and total parenteral nutrition in patients with acute pancreatitis. Gastroenterol Res Pract 2011; 2011: 698248.

    Article  Google Scholar 

  2. Guzy C, Schirbel A, Paclik D, Wiedenmann B, Dignass A, Sturm A . Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro. Eur J Nutr 2009; 48: 12–21.

    Article  CAS  Google Scholar 

  3. McClave SA, Martindale RG, Rice TW, Heyland DK . Feeding the critically ill patient. Crit Care Med 2014; 42: 2600–2610.

    Article  Google Scholar 

  4. Yi F, Ge L, Zhao J, Lei Y, Zhou F, Chen Z et al. Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis. Intern Med 2012; 51: 523–530.

    Article  Google Scholar 

  5. Wang GL, Wen JB, Xu LF, Zhou SF, Gong M, Wen P et al. Effect of enteral nutrition and ecoimmunonutrition on bacterial translocation and cytokine production in patients with severe acute pancreatitis. J Surg Res 2013; 183: 592–597.

    Article  CAS  Google Scholar 

  6. Wu XM, Ji KQ, Wang HY, Li GF, Zang B, Chen WM . Total enteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis. Pancreas 2010; 39: 248–251.

    Article  CAS  Google Scholar 

  7. Casas M, Mora J, Fort E, Aracil C, Busquets D, Galter S et al. Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis. Rev Esp Enferm Dig 2007; 99: 264–269.

    Article  CAS  Google Scholar 

  8. Kalfarentzos F, Kehagias J, Mead N, Kokkinis K, Gogos CA . Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 1997; 84: 1665–1669.

    Article  CAS  Google Scholar 

  9. Sun JK, Mu XW, Li WQ, Tong ZH, Li J, Zheng SY . Effects of early enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol 2013; 19: 917–922.

    Article  CAS  Google Scholar 

  10. Vasilescu C, Herlea V, Buttenschoen K, Beger HG . Endotoxin translocation in two models of experimental acute pancreatitis. J Cell Mol Med 2003; 7: 417–424.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Intensive Care Unit of the Affiliated Nanhua Hospital, University of South China, Hengyang, China

    H Yao, C He, L Deng & G Liao

Authors
  1. H Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C He
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Liao.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on European Journal of Clinical Nutrition website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yao, H., He, C., Deng, L. et al. Enteral versus parenteral nutrition in critically ill patients with severe pancreatitis: a meta-analysis. Eur J Clin Nutr 72, 66–68 (2018). https://doi.org/10.1038/ejcn.2017.139

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2017.139

This article is cited by

Search

Advanced search

Quick links