Therapeutic lifestyle change diet enriched in legumes reduces oxidative stress in overweight type 2 diabetic patients: a crossover randomised clinical trial

Abstract

The objective of this study was to investigate whether a diet rich in legumes are associated with oxidative stress among type 2 diabetic patients. In a randomized, controlled, crossover clinical trial, 31 type 2 diabetic patients were randomly assigned to receive 2 diets, each for a period of 8 weeks: (1) The legume-free therapeutic lifestyle change (TLC) diet and (2) the legume-based TLC diet. Both diets were similar except that 2 servings of red meat were replaced by different types of legumes 3 days per week in the legume-based TLC diet. Oxidative stress biomarkers were measured at baseline and after 8 weeks. Compared to the legume-free TLC diet, the legume-based TLC diet significantly decreased malondialdehyde (−0.22 versus −0.68 μmol/l; P=0.002), oxidized-LDL (−0.9 versus −2.3 mU/l; P=0.05) and increased nitric oxide (0.40 versus 0.96 mM/l; P=0.03) and catalase activity (1.2 versus 2.1 Iu/ml; P=0.05).

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Acknowledgements

The authors would like to thank the participants who participated in the present study. The authors wish to express their appreciation to Ms N Shiva for critical editing of English grammar and syntax of the manuscript. This work was supported by the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (grant 411). This work was supported by the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (grant 411). The project idea for this study was from SH-N and PM. The project was designed by PM, SH-N and FA; SHN analyzed and interpreted the data; SHN and PM prepared the manuscript. All authors have read and approved the final manuscript. Overall FA supervised the project and approved the final version of the manuscript to be submitted.

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Correspondence to S Hosseinpour-Niazi.

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Mirmiran, P., Hosseinpour-Niazi, S. & Azizi, F. Therapeutic lifestyle change diet enriched in legumes reduces oxidative stress in overweight type 2 diabetic patients: a crossover randomised clinical trial. Eur J Clin Nutr 72, 174–176 (2018). https://doi.org/10.1038/ejcn.2017.113

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