Clinical Nutrition

Effect of body mass index on overall survival of patients with allogeneic hematopoietic stem cell transplantation

Subjects

Abstract

Background/Objectives:

The present work was performed to investigate the association between body mass index (BMI) before transplantation and the overall survival (OS) of patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Subjects/Methods:

Data from 310 adults who were diagnosed with acute leukemia and underwent allo-HSCT between March 2001 and December 2011 were analyzed. According to the suggested BMI categories for Asian population, patients with BMIs of 23 and 25 kg/m2 were identified as overweight and obese, respectively. Cox proportional hazards models was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).

Results:

The median follow-up time among the patients was 19.7 months (interquartile range=8.1–37.7). A total of 93 (34.8%) people died within the follow-up period. After adjusting for the potential confounders, normal-weight, overweight and obese patients showed significantly lower HRs than those of underweight patients, with a significant trend of OS improvement upon increasing BMI (P=0.019). Overweight and obese patients survived longer, with a significantly decreased HR by ~40% (HR=0.60; 95% CI: 0.38–0.95) compared with underweight and normal-weight patients.

Conclusions:

An increased OS was seen in allo-HSCT patients with BMI23 kg/m2 compared to those with lower BMI. Further work are still needed to investigate of the effects of BMI or body composition on the survival of allo-HSCT patients.

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Acknowledgements

We thank members of Department of Hematology for excellent work.

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Correspondence to Y-P Shen or D-P Wu.

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Yang, J., Xue, SL., Zhang, X. et al. Effect of body mass index on overall survival of patients with allogeneic hematopoietic stem cell transplantation. Eur J Clin Nutr 71, 750–754 (2017). https://doi.org/10.1038/ejcn.2016.225

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