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Dietary patterns, food groups and telomere length: a systematic review of current studies

Abstract

Telomere length (TL) is recognized as a biomarker of aging and shorter telomeres are linked with shorter lifespan. Inter-individual variability in telomere length is highly heritable. However, there has been a resurgence of interest in the controversial relationship between diet and TL. Evaluating the impact of diet at the food group and dietary pattern level will provide greater insight into the effect of diet on TL dynamics, which are of significant importance in health and longevity. This article reports the first systematic review of the relation between food groups, dietary patterns and TL in human populations based on PRISMA guidelines. Design: PubMed, Science Direct, The Cochrane Library and Google Scholar databases were electronically searched for all relevant studies, up to November 2015. Among the 17 included studies, 3 and 10 of them were regarding the effect of dietary patterns and various food groups on TL, respectively. Also, in 4 studies, both dietary patterns and different food groups were assessed in relation to TL. Mediterranean dietary pattern was related to longer TL in 3 studies. Five studies indicated beneficial effect of fruits or vegetables on TL. In 7 studies, a reverse association between TL and intake of cereals, processed meat, and fats and oils was reported. Our systematic review supports the health benefits of adherence to Mediterranean diet on TL. Except for the fruits and vegetables, which showed positive association with TL, results were inconsistent for other dietary factors. Also, certain food categories including processed meat, cereals and sugar-sweetened beverages may be associated with shorter TLs. However, additional epidemiological evidence and clinical trials should be considered in future research in order to develop firm conclusions in this regard.

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References

  1. Blackburn EH . Structure and function of telomeres. Nature 1991; 350: 569–573.

    Article  CAS  PubMed  Google Scholar 

  2. Aviv A . Telomeres and human aging: facts and fibs. Sci Aging Knowledge Environ 2004; 2004: pe43.

    Article  PubMed  Google Scholar 

  3. von Zglinicki T . Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27: 339–344.

    Article  CAS  PubMed  Google Scholar 

  4. Blasco MA . Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 2005; 6: 611–622.

    Article  CAS  PubMed  Google Scholar 

  5. Calado RT, Young NS . Telomere diseases. N Engl J Med 2009; 361: 2353–2365.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P . Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 2014; 349: g4227.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Du M, Prescott J, Kraft P, Han J, Giovannucci E, Hankinson SE et al. Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol 2012; 175: 414–422.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Okereke OI, Prescott J, Wong JY, Han J, Rexrode KM, De Vivo I . High phobic anxiety is related to lower leukocyte telomere length in women. PLoS One 2012; 7: e40516.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Prescott J, Du M, Wong JY, Han J, De Vivo I . Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study. Hum Reprod 2012; 27: 3622–3631.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Crous-Bou M, Fung TT, Prescott J, Julin B, Du M, Sun Q et al. Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ 2014; 349: g6674.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Farsinejad-Marj M, Talebi S, Ghiyasvand R, Miraghajani M . Adherence to Mediterranean diet and risk of breast cancer in premenopausal and postmenopausal women. Arch Iran Med 2015; 18: 786–792.

    PubMed  Google Scholar 

  12. Golpour S, Rafie N, Safavi SM, Miraghajani M . Dietary isoflavones and gastric cancer: a brief review of current studies. J Res Med Sci 2015; 20: 893.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Jolfaie NR, Mirzaie S, Ghiasvand R, Askari G, Miraghajani M . The effect of glutamine intake on complications of colorectal and colon cancer treatment: a systematic review. J Res Med Sci 2015; 20: 910.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE et al. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 2004; 80: 1029–1035.

    Article  CAS  PubMed  Google Scholar 

  15. Rafie N, Golpour Hamedani S, Ghiasvand R, Miraghajani M . Kefir and cancer: a systematic review of literatures. Arch Iran Med 2015; 18: 852–857.

    PubMed  Google Scholar 

  16. Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G . Mediterranean diet, telomere maintenance and health status among elderly. PLoS ONE 2013; 8: e62781.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Gu Y, Honig LS, Schupf N, Lee JH, Luchsinger JA, Stern Y et al. Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population. Age (Dordr) 2015; 37: 24.

    Article  Google Scholar 

  18. Tiainen AM, Mannisto S, Blomstedt PA, Moltchanova E, Perala MM, Kaartinen NE et al. Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. Eur J Clin Nutr 2012; 66: 1290–1294.

    Article  CAS  PubMed  Google Scholar 

  19. Wells G, Shea B, O’connell D, Peterson J, Welch V, Losos M et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses; 2000.

  20. Lee JY, Jun NR, Yoon D, Shin C, Baik I . Association between dietary patterns in the remote past and telomere length. Eur J Clin Nutr 2015; 69: 1048–1052.

    Article  PubMed  Google Scholar 

  21. Nettleton JA, Diez-Roux A, Jenny NS, Fitzpatrick AL, Jacobs DR Jr. . Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 2008; 88: 1405–1412.

    Article  CAS  PubMed  Google Scholar 

  22. Pellatt AJ, Wolff RK, Lundgreen A, Cawthon R, Slattery ML . Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. Int J Mole Epidemiol Genet 2012; 3: 184–194.

    CAS  Google Scholar 

  23. Sun Q, Shi L, Prescott J, Chiuve SE, Hu FB, De Vivo I et al. Healthy lifestyle and leukocyte telomere length in U.S. women. PLoS ONE 2012; 7: e38374.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Chiuve SE, Fung TT, Rimm EB, Hu FB, McCullough ML, Wang M et al. Alternative dietary indices both strongly predict risk of chronic disease. J Nutr 2012; 142: 1009–1018.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell 2007; 6: 639–647.

    Article  CAS  PubMed  Google Scholar 

  26. Cassidy A, De Vivo I, Liu Y, Han J, Prescott J, Hunter DJ et al. Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr 2010; 91: 1273–1280.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Chan R, Woo J, Suen E, Leung J, Tang N . Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br J Nutr 2010; 103: 107–113.

    Article  CAS  PubMed  Google Scholar 

  28. Garcia-Calzon S, Moleres A, Martinez-Gonzalez MA, Martinez JA, Zalba G, Marti A . Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population. Clin Nutr 2015; 34: 694–699.

    Article  CAS  PubMed  Google Scholar 

  29. Hou L, Savage SA, Blaser MJ, Perez-Perez G, Hoxha M, Dioni L et al. Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev 2009; 18: 3103–3109.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Marcon F, Siniscalchi E, Crebelli R, Saieva C, Sera F, Fortini P et al. Diet-related telomere shortening and chromosome stability. Mutagenesis 2012; 27: 49–57.

    Article  CAS  PubMed  Google Scholar 

  31. Mirabello L, Huang WY, Wong JY, Chatterjee N, Reding D, Crawford ED et al. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell 2009; 8: 405–413.

    Article  CAS  PubMed  Google Scholar 

  32. Song Y, You NC, Song Y, Kang MK, Hou L, Wallace R et al. Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women. J Nutr 2013; 143: 907–914.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Leung CW, Laraia BA, Needham BL, Rehkopf DH, Adler NE, Lin J et al. Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys. Am J Public Health 2014; 104: 2425–2431.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, Lu X et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet 2006; 78: 480–486.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Slagboom PE, Droog S, Boomsma DI . Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994; 55: 876–882.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kolvraa S, Christensen K et al. The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell 2004; 3: 97–102.

    Article  CAS  PubMed  Google Scholar 

  37. Henle ES, Han Z, Tang N, Rai P, Luo Y, Linn S . Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications. J Biol Chem 1999; 274: 962–971.

    Article  CAS  PubMed  Google Scholar 

  38. Aviv A . Leukocyte telomere length: the telomere tale continues. Am J Clin Nutr 2009; 89: 1721–1722.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006; 5: 325–330.

    Article  CAS  PubMed  Google Scholar 

  40. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 2005; 111: 2171–2177.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We would like to thank the Isfahan University of Medical Sciences for their great cooperation in conducting this study. The gauarantor of this article is M Miraghajani.

Author contributions

NR, SG, FB, SMS and MM conceptualized and designed the study, and drafted the manuscript.

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Correspondence to M Miraghajani.

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The authors declare no conflict of interest.

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Rafie, N., Golpour Hamedani, S., Barak, F. et al. Dietary patterns, food groups and telomere length: a systematic review of current studies. Eur J Clin Nutr 71, 151–158 (2017). https://doi.org/10.1038/ejcn.2016.149

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