Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lipids and cardiovascular/metabolic health

Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults




Effects of high-protein diets that are rich in saturated fats on cell adhesion molecules, thrombogenicity and other nonlipid markers of atherosclerosis in humans have not been firmly established. We aim to investigate the effects of high-protein Malaysian diets prepared separately with virgin olive oil (OO), palm olein (PO) and coconut oil (CO) on cell adhesion molecules, lipid inflammatory mediators and thromobogenicity indices in healthy adults.


A randomized cross-over intervention with three dietary sequences, using virgin OO, PO and CO as test fats, was carried out for 5 weeks on each group consisting of 45 men and women. These test fats were incorporated separately at two-thirds of 30% fat calories into high-protein Malaysian diets.


For fasting and nonfasting blood samples, no significant differences were observed on the effects of the three test-fat diets on thrombaxane B2 (TXB2), TXB2/PGF ratios and soluble intracellular and vascular cell adhesion molecules. The OO diet induced significantly lower (P<0.05) plasma leukotriene B4 (LTB4) compared with the other two test diets, whereas PGF concentrations were significantly higher (P<0.05) at the end of the PO diet compared with the OO diet.


Diets rich in saturated fatty acids from either PO or CO and high in monounsaturated oleic acid from virgin OO do not alter the thrombogenicity indices—cellular adhesion molecules, thromboxane B2 (TXB2) and TXB2/prostacyclin (PGF) ratios. However, the OO diet lowered plasma proinflammatory LTB4, whereas the PO diet raised the antiaggregatory plasma PGF in healthy Malaysian adults. This trial was registered at as NCT 00941837.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Konstantopoulos K, McIntire LV . Effects of fluid dynamic forces on vascular cell adhesion. J Clin Invest 1996; 98: 2661–2665.

    Article  CAS  Google Scholar 

  2. Braun M, Pietsch P, Schror K, Baumann G, Felix SB . Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc Res 1999; 41: 395–401.

    Article  CAS  Google Scholar 

  3. Petruzzelli L, Takami M, Humes HD . Structure and function of cell adhesion molecules. Am J Med 1999; 106: 467–476.

    Article  CAS  Google Scholar 

  4. Hamberg M, Svensson J, Samuelsson B . Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 1975; 72: 2994–2998.

    Article  CAS  Google Scholar 

  5. Bhagwat SS, Hamann PR, Still WC, Bunting S, Fitzpatrick FA . Synthesis and structure of the platelet aggregation factor thromboxane A2. Nature 1985; 315: 511–513.

    Article  CAS  Google Scholar 

  6. Moncada S, Gryglewski R, Bunting S, Vane JR . An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663–665.

    Article  CAS  Google Scholar 

  7. Vane JR, Anggard EE, Botting RM . Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27–36.

    Article  CAS  Google Scholar 

  8. Lehr R . Sixteen S-squared over D-squared: a relation for crude sample size estimates. Stat Med 1992; 11: 1099–1102.

    Article  CAS  Google Scholar 

  9. Sanders TAB, Oakley F, Yahia N, T DG . Influence of variation in fat composition on haemostatic variables. Asia Pac J Clin Nutr 1997; 6: 3.

    CAS  PubMed  Google Scholar 

  10. Tholstrup T, Miller GJ, Bysted A, Sandstrom B . Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men. Am J Clin Nutr 2003; 77: 1125–1132.

    Article  CAS  Google Scholar 

  11. Ng TK, Hayes KC, DeWitt GF, Jegathesan M, Satgunasingam N, Ong AS et al. Dietary palmitic and oleic acids exert similar effects on serum cholesterol and lipoprotein profiles in normocholesterolemic men and women. J Am Coll Nutr 1992; 11: 383–390.

    Article  CAS  Google Scholar 

  12. Chee S, Ismail M, Ng K, Zawiah H . Food intake assessment of adults in rural and urban areas from four selected regions in Malaysia. Mal J Nutr 1997; 3: 91–102.

    Google Scholar 

Download references


We thank all staff and colleagues from the Nutrition Laboratory of the Malaysian Palm Oil Board (MPOB) for their help in conducting the study. We also thank the Director General of MPOB for permission to publish the data. This work was supported by the grants from Malaysian Palm Oil Board.

Author information

Authors and Affiliations


Corresponding author

Correspondence to P T Voon.

Ethics declarations

Competing interests

PTV and KN are Research Officers of Malaysian Palm Oil Board, a fully government research institution. TKWN and KMVL declares no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Voon, P., Ng, T., Lee, V. et al. Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults. Eur J Clin Nutr 69, 712–716 (2015).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links