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Carbohydrates, glycemic index and diabetes mellitus

Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation




The objective of this study was to determine the postprandial change in free fatty acid (FFA) profiles in subjects with impaired fasting glucose (IFG), and to evaluate the effect of low glycemic index (GI) load on postprandial FFA profiles and inflammation.


First, 50 IFG and 50 healthy subjects were recruited; and 2 -h postprandial changes in FFA profiles were determined. Second, the 50 IFG subjects then received three different loads: glucose load (GL), high glycemic index (HGI) load and low glycemic index (LGI) load, respectively. FFA profile, glucose, insulin, glucagon-like peptide 1 (GLP-1) and inflammatory biomarkers were assayed at 0, 30, 60, 90 and 120 min.


Postprandial stearic acid (C18:0) increased compared with baseline in all subjects, whereas the change in postprandial C18:0 was more marked in IFG subjects than in healthy subjects. Compared with subjects who received the GL and HGI load, the area under the curve for insulin, GLP-1, C18:0 and tumor necrosis factor-alpha significantly decreased and adiponectin increased in subjects who received the LGI load.


The rise in postprandial C18:0 in IFG subjects was inhibited by LGI load.

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Funding was provided by Program for New Century Excellent Talents In Heilongjiang Provincial University (No. 1254-NCET-013), Postdoctoral Science Foundation of China (No. 2014M551280) and Natural Science Foundation of China Key Project (No. 81130049). The trial registry number is ChiCTR-TRC-12002630.

Author contributions

CS is the guarantor of this work and had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. LL, YL and CS contributed to the conception and design. LL, XC and LN wrote the manuscript and researched data. All authors contributed to the drafting of the article and gave final approval of the version to be published.

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Correspondence to Y Li or C Sun.

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Supplementary Information accompanies this paper on European Journal of Clinical Nutrition website

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Liu, L., Chu, X., Na, L. et al. Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. Eur J Clin Nutr 70, 795–801 (2016).

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