Table 4 Cancer risks for users at both recording points, and for past/new users compared with never-users, according to any supplement use at baseline and second survey in the UK Women’s Cohort Study (N=12 948)

From: General supplement use, subsequent use and cancer risk in the UK Women’s Cohort Study

Any supplements use at baseline or second survey Cases/non-cases Unadjusted hazard ratio (95% confidence interval) Adjusted a b hazard ratio (95% confidence interval)
Total cancers
 Never users at both 334/2431 1 1
 Past/new users 343/2830 0.88 (0.75, 1.04) 0.96 (0.81, 1.14)
 Users at both 850/6160 1.01 (0.89, 1.16) 1.01 (0.88, 1.17)
Smoking-related cancers
 Never users at both 27/2738 1 1
 Past/new users 27/3146 0.78 (0.44, 1.37) 0.97 (0.53, 1.79)
 Users at both 77/6933 1.10 (0.70, 1.75) 1.29 (0.78, 2.13)
Colorectal cancer
 Never users at both 35/2730 1 1
 Past/new users 27/3145 0.62 (0.36, 1.07) 0.71 (0.40, 1.26)
 Users at both 79/6931 0.95 (0.62, 1.44) 1.00 (0.63, 1.57)
Breast cancer all women
 Never users at both 110/2655 1 1
 Past/new users 132/3041 1.03 (0.79, 1.34) 0.98 (0.73, 1.30)
 Users at both 319/6691 1.13 (0.90, 1.42) 1.08 (0.85, 1.38)
Breast cancer postmenopausal
 Never users at both 71/1379 1 1
 Past/new users 71/1427 0.95 (0.67, 1.33) 0.90 (0.62, 1.31)
 Users at both 189/3619 1.00 (0.75, 1.32) 0.93 (0.68, 1.26)
Breast cancer premenopausal
 Never users at both 39/1276 1 1
 Past/new users 61/1614 1.25 (0.81, 1.94) 1.17 (0.74, 1.84)
 Users at both 130/3072 1.40 (0.95, 2.08) 1.35 (0.91, 2.01)
  1. aAll cancer, smoking-related cancer and colorectal cancer analyses adjusted for baseline covariates: age, body mass index, education, hours exercise sweating per week, alcohol intake, total energy intake, smoking habit, diet type.
  2. bBreast cancer analysis adjusted for baseline covariates: age, body mass index, education, hours exercise sweating per week, alcohol intake, total energy intake, diet type, parity, age at menarche, contraceptive pill use, hormone replacement therapy use.