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Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women

European Journal of Clinical Nutrition volume 68, pages 635–637 (2014)Cite this article

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Abstract

Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was carried out 7 days later. Six men and six women were included. A favorable reduction in AIx was found after vitamin D3 supplementation (P=0.042) in both genders. After vitamin D3, exclusively in women a reduction in the area under the postprandial curve for monocytes CD11b and CD35 by 10.5% (P=0.016) and 12.5% (P=0.04) and neutrophil CD11b by 17.0% (P=0.014) was observed. In conclusion, vitamin D3 probably increased postprandial arterial elasticity in men and women, but reduced postprandial leukocyte activation exclusively in women.

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References

  1. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M et al. Effect of vitamin d deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94: 4023–4030.

    Article  CAS  Google Scholar 

  2. Dong Y, Stallmann-Jorgensen IS, Pollock NK, Harris RA, Keeton D, Huang Y et al. A 16-week randomized clinical trial of 2000 international units daily vitamin d3 supplementation in black youth: 25-hydroxyvitamin d, adiposity, and arterial stiffness. J Clin Endocrinol Metab 2010; 95: 4584–4591.

    Article  CAS  Google Scholar 

  3. Ross R . Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340: 115–126.

    Article  CAS  Google Scholar 

  4. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM et al. Cd11c/cd18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol 2011; 31: 160–166.

    Article  CAS  Google Scholar 

  5. Berry SE, Tucker S, Banerji R, Jiang B, Chowienczyk PJ, Charles SM et al. Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J Nutr 2008; 138: 1910–1914.

    Article  CAS  Google Scholar 

  6. Klop B, van de Geijn GJ, Njo TL, Janssen HW, Rietveld AP, van Miltenburg A et al. Leukocyte cell population data (volume conductivity scatter) in postprandial leukocyte activation. Int J Lab Hematol 2013; 6: 644–651.

    Article  Google Scholar 

  7. Spittler A, Willheim M, Leutmezer F, Ohler R, Krugluger W, Reissner C et al. Effects of 1 alpha,25-dihydroxyvitamin D3 and cytokines on the expression of MHC antigens, complement receptors and other antigens on human blood monocytes and u937 cells: role in cell differentiation, activation and phagocytosis. Immunology 1997; 90: 286–293.

    Article  CAS  Google Scholar 

  8. Correale J, Ysrraelit MC, Gaitan MI . Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects. J Immunol 2010; 185: 4948–4958.

    Article  CAS  Google Scholar 

  9. Cutini PH, Campelo AE, Agriello E, Sandoval MJ, Rauschemberger MB, Massheimer VL . The role of sex steroids on cellular events involved in vascular disease. J Steroid Biochem Mol Biol 2012; 132: 322–330.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands,

    B Klop, J W F Elte & M Castro Cabezas

  2. Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands,

    G-JM van de Geijn, T L Njo & H W Janssen

  3. Department of Statistics and Education, Sint Franciscus Gasthius, Rotterdam, The Netherlands,

    E Birnie

  4. Department of Clinical Pharmacy, Sint Franciscus Gasthuis, Rotterdam, The Netherlands

    H G Jansen

  5. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

    J W Jukema

  6. Interuniversity Cardiology Institute of The Netherlands (ICIN), Utrecht, The Netherlands

    J W Jukema

Authors
  1. B Klop
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  2. G-JM van de Geijn
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  3. E Birnie
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  4. T L Njo
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  5. H W Janssen
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  6. H G Jansen
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  7. J W Jukema
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  8. J W F Elte
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  9. M Castro Cabezas
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Corresponding author

Correspondence to M Castro Cabezas.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on European Journal of Clinical Nutrition website

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Klop, B., van de Geijn, GJ., Birnie, E. et al. Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women. Eur J Clin Nutr 68, 635–637 (2014). https://doi.org/10.1038/ejcn.2014.29

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  • DOI: https://doi.org/10.1038/ejcn.2014.29

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