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Nutrition Epidemiology Highlights Review

Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factors

European Journal of Clinical Nutrition volume 69, pages 411–418 (2015)Cite this article

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Abstract

The identification of a hot spot of exceptional longevity, the Longevity Blue Zone (LBZ), in the mountain population of Sardinia has aroused considerable interest toward its traditional food as one of the potential causal factors. This preliminary study on the traditional Sardinian diet has been supported by the literature available, which has been carefully reviewed and compared. Up to a short time ago, the LBZ population depended mostly upon livestock rearing, and consumption of animal-derived foods was relatively higher than in the rest of the island. The nutrition transition (NT) in urbanized and lowland areas began in the mid-1950s, fueled by economic development, whereas in the LBZ it started later owing to prolonged resistance to change by a society organized around a rather efficient pastoral economy. Even nowadays a large proportion of the population in this area still follows the traditional diet based on cereal-derived foods and dairy products. The LBZ cohorts comprising individuals who were of a mature age when NT began may have benefited both from the high-quality, albeit rather monotonous, traditional diet to which they had been exposed most of their life and from the transitional diet, which introduced positive changes such as more variety, increased consumption of fruits and vegetables and moderate meat intake. It could be speculated that these changes may have brought substantial health benefits to this particular aging group, which was in need of nutrient-rich food at this specific time in life, thereby resulting in a decreased mortality risk and, in turn, life-span extension.

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References

  1. Poulain M, Pes GM, Grasland C, Carru C, Ferrucci L, Baggio G et al. Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol 2004; 39: 1423–1429.

    Article  Google Scholar 

  2. Poulain M, Pes GM, Salaris L . A population where men live as long as women: Villagrande Strisaili, Sardinia. J Aging Res 2011; 2011: 153756.

    Article  Google Scholar 

  3. Pes GM, Tolu F, Poulain M, Errigo A, Masala S, Pietrobelli A et al. Lifestyle and nutrition related to male longevity in Sardinia: an ecological study. Nutr Metab Cardiovasc Dis 2013; 23: 212–219.

    Article  CAS  Google Scholar 

  4. Buffa R, Floris G, Lodde M, Cotza M, Marini E . Nutritional status in the healthy longeval population from Sardinia (Italy). J Nutr Health Aging 2010; 14: 97–102.

    Article  CAS  Google Scholar 

  5. Tessier S, Gerber M . Factors determining the nutrition transition in two Mediterranean islands: Sardinia and Malta. Public Health Nutr 2005; 8: 1286–1292.

    Article  Google Scholar 

  6. Tessier S, Gerber M . Comparison between Sardinia and Malta: the Mediterranean diet revisited. Appetite 2005; 45: 121–126.

    Article  Google Scholar 

  7. Lissia S . La Gallura, studi storico-sociali. Tipografia Tortu: Tempio Pausania, Italy, 1903.

    Google Scholar 

  8. Tore G . Ricerche sull’alimentazione e sul consumo alimentare nella Sardegna del XVIII e XIX secolo. Mélanges de l’Ecole Française de Rome 1975; 87: 597–615.

    Article  Google Scholar 

  9. Tivaroni J . Nutrition patterns in the Sardinia population. Riv Pol Econ 1928; 2: 1–11.

    Google Scholar 

  10. Fermi C . Sardegna (voll. 1–3). In: Regioni malariche: decadenza, risanamento e spesa. Tipografica editrice di Roma S. A.: Roma, Italy, 1934.

    Google Scholar 

  11. Peretti G . Rapporti tra alimentazione e caratteri antropometrici. Studio statistico-biometrico in Sardegna. Quad Nutr 1943; 9: 69–130.

    Google Scholar 

  12. Peretti G . Research on nutrition in Sardinia; food habits among the rural population in Sardinia, in an economically depressed region. Boll Soc Ital Biol Sper 1957; 33: 36–38.

    CAS  PubMed  Google Scholar 

  13. Brotzu G, Food conditions. Proceedings of the International Congress for The Study of The Problem of Underdeveloped Areas; 10–15 October; Milan, Italy, 1954.

  14. Carbini L . Evoluzione del comportamento alimentare nei sardi dal secondo dopoguerra ad oggi. In: Floris G, Sanna E (eds). L’uomo in Sardegna. Aspetti di antropobiologia ed ecologia umana. Zonza Editori: Quartu S. Elena, Italy, 1998.

    Google Scholar 

  15. Sanna E . Il popolamento della Sardegna e le origini dei sardi. CUEC: Cagliari, Italy, 2006.

    Google Scholar 

  16. Angioni G . La cultura tradizionale. In: Brigaglia M (ed). La Sardegna: la cultura popolare, l’economia, l’autonomia. Edizioni della Torre: Cagliari, Italy, 1982.

    Google Scholar 

  17. Garnsey P . Famine and food supply in the Græco–Roman world. Responses to risk and crisis. Cambridge University Press: Cambridge, UK, 1988.

    Google Scholar 

  18. Segreti A . L'alimentazione monastica nel territorio algherese tra Sette e Ottocento. Rev l'Alguer 1992; 3: 117–136.

    Google Scholar 

  19. Delitala E . Trasformazioni e recuperi nel regime alimentare italiano. Il caso Sardegna. Brads 1982–83; 11: 16–25.

    Google Scholar 

  20. Angius V . Sardegna (Voll. XVIII-XIX). In: Casalis G (ed). Dizionario geografico, storico, statistico–commerciale degli Stati di S.M. il Re di Sardegna. G. Maspero: Torino, Italy, 1842.

    Google Scholar 

  21. Le Lannou M . Pâtres et paysans de la Sardaigne. Arrault et Cie: Tours, France, 1941.

    Google Scholar 

  22. Naska A, Fouskakis D, Oikonomou E, Almeida MD, Berg MA, Gedrich K et al. Dietary patterns and their socio-demographic determinants in 10 European countries: data from the DAFNE databank. Eur J Clin Nutr 2006; 60: 181–190.

    Article  CAS  Google Scholar 

  23. Loi MC, Poli F, Sacchetti G, Selenu MB, Ballero M . Ethnopharmacology of ogliastra (Villagrande Strisaili, Sardinia, Italy). Fitoterapia 2004; 75: 277–295.

    Article  CAS  Google Scholar 

  24. Tessier S, Alimentation méditerranéenne, insularité et développement. Thèse de doctorat http://tel.archives-ouvertes.fr/docs/00/04/73/85/PDF/tel-00007599.pdf. 2004.

  25. Mondardini G . Villaggi di pescatori in Sardegna: disgregazione e rurbanizzazione. In: Merler A (ed). Tempo spazio società. Centro Iniziative Culturali: Sassari, Italy, 1981.

    Google Scholar 

  26. Cottino A, Morgan P . Four country profiles: Italy. In: Grant M (ed). Alcohol Policies, WHO Regional Publications, European series No 18. WHO Regional Office for Europe: Copenhagen, Denmark, 1985.

    Google Scholar 

  27. Brotzu G . Indagine sui benestanti della città di Cagliari.. Istituto Nazionale della Nutrizione: Quad Nutr, Roma, Italy, 1938.

    Google Scholar 

  28. Kim S, Moon S, Popkin BM . The nutrition transition in South Korea. Am J Clin Nutr 2000; 71: 44–53.

    Article  CAS  Google Scholar 

  29. La Sardegna . Otto anni di autonomia (1949-1957). Società Editoriale Italiana: Cagliari, 1957.

    Google Scholar 

  30. Salzman PC, Post-modernism and pastoralism: cultural dialectics in Highland Sardinia. Paper presented at the International Congress on ‘Il pastoralismo mediterraneo’. ISRE: Nuoro, Italy, 1991.

  31. He Q, Morris BJ, Grove JS, Petrovitch H, Ross W, Masaki KH et al. Shorter men live longer: association of height with longevity and FOXO3 genotype in American men of Japanese ancestry. PLoS One 2014; 9: e394385.

    Google Scholar 

  32. Samaras TT . Evidence from eight different types of studies showing that smaller body size is related to greater longevity. J Sci Res Rep 2014; 3: 2150–2160.

    Google Scholar 

  33. Salaris L, Poulain M, Samaras TT . Height and survival at older ages among men born in an inland village in Sardinia (Italy), 1866–2006. Biodemography Soc Biol 2012; 58: 1–13.

    Article  Google Scholar 

  34. Kirchengast S . Gender differences in body composition from childhood to old age: an evolutionary point of view. J Life Sci 2010; 2: 1–10.

    Article  Google Scholar 

  35. Collins JL, Lehnherr J, Posner SF, Toomey KE . Ties that bind: maternal and child health and chronic disease prevention at the Centers for Disease Control and Prevention. Prev Chronic Dis 2009; 6: A01.

    PubMed  Google Scholar 

  36. Fontana L, Partridge L, Longo VD . Extending healthy life span – from yeast to humans. Science 2010; 328: 321–326.

    Article  CAS  Google Scholar 

  37. Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986; 124: 903–915.

    Article  CAS  Google Scholar 

  38. Corder R, Mullen W, Khan NQ, Marks SC, Wood EG, Carrier MJ et al. Oenology: red wine procyanidins and vascular health. Nature 2006; 444: 566.

    Article  CAS  Google Scholar 

  39. Hitchins AD, McDonough FE . Prophylactic and therapeutic aspects of fermented milk. Am J Clin Nutr 1989; 49: 675–684.

    Article  CAS  Google Scholar 

  40. Sinha R, Cross AJ, Graubard BI, Leitzmann MF, Schatzkin A . Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med 2009; 169: 562–571.

    Article  CAS  Google Scholar 

  41. de Lorgeril M . Mediterranean diet in the prevention of coronary heart disease. Nutrition 1998; 14: 55–57.

    Article  CAS  Google Scholar 

  42. Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E et al. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One 2011; 6: e20456.

    Article  CAS  Google Scholar 

  43. Singh PN, Sabaté J, Fraser GE . Does low meat consumption increase life expectancy in humans? Am J Clin Nutr 2003; 78 (3 Suppl), 526S–532S.

    Article  CAS  Google Scholar 

  44. Miyagi S, Iwama N, Kawabata T, Hasegawa K . Longevity and diet in Okinawa, Japan: the past, present and future. Asia Pac J Public Health 2003; 15 (Suppl), S3–S9.

    Article  Google Scholar 

  45. Panagiotakos DB, Chrysohoou C, Siasos G, Zisimos K, Skoumas J, Pitsavos C et al. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in Ikaria island: the Ikaria study. Cardiol Res Pract 2011; 2011: 679187.

    Article  Google Scholar 

  46. Rosero-Bixby L, Dow WH, Rehkopf DH . The Nicoya region of Costa Rica: a high longevity island for elderly males. Vienna Yearb Popul Res 2013; 11: 109–136.

    Article  Google Scholar 

  47. Beasley JM, Shikany JM, Thomson CA . The role of dietary protein intake in the prevention of sarcopenia of aging. Nutr Clin Pract 2013; 28: 684–690.

    Article  Google Scholar 

  48. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab 2014; 19: 407–417.

    Article  CAS  Google Scholar 

  49. Berti F, Manfredi B, Mantegazza P, Rossoni G . Procyanidins from Vitis vinifera seeds display cardioprotection in an experimental model of ischemia-reperfusion damage. Drugs Exp Clin Res 2003; 29: 207–216.

    CAS  PubMed  Google Scholar 

  50. Chen W, Rezaizadehnajafi L, Wink M . Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 2013; 65: 682–688.

    Article  CAS  Google Scholar 

  51. da Luz PL, Tanaka L, Brum PC, Dourado PM, Favarato D, Krieger JE et al. Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats. Atherosclerosis 2012; 224: 136–142.

    Article  CAS  Google Scholar 

  52. Maioli M, Pes GM, Sanna M, Cherchi S, Dettori M, Manca E et al. Sourdough-leavened bread improves postprandial glucose and insulin plasma levels in subjects with impaired glucose tolerance. Acta Diabetol 2008; 45: 91–96.

    Article  CAS  Google Scholar 

  53. Murru-Corriga G . La panificazione dell'orzo in Barbagia. In: Papa C (ed). Il Pane, Electa Editori Umbri: Perugia, Italy, 1992.

    Google Scholar 

  54. Behall KM, Scholfield DJ, Hallfrisch J . Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am J Clin Nutr 2004; 80: 1185–1193.

    Article  CAS  Google Scholar 

  55. Hänlein GFW . Goat milk in human nutrition. Small Rumin Res 2004; 51: 155–163.

    Article  Google Scholar 

  56. Lopez-Aliaga I, Dìaz–Castro J, Alferez MJ, Barrionuevo M, Campos MS . A review of the nutritional and health aspects of goat milk in cases of intestinal resection. Dairy Sci Technol 2010; 90: 611–622.

    Article  CAS  Google Scholar 

  57. Alférez MJ, Barrionuevo M, López Aliaga I, Sanz-Sampelayo MR, Lisbona F, Robles JC et al. Digestive utilization of goat and cow milk fat in malabsorption syndrome. J Dairy Res 2001; 68: 451–461.

    Article  Google Scholar 

  58. Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA . The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 2002; 132: 1012–1017.

    Article  CAS  Google Scholar 

  59. Fushiki T, Matsumoto K, Inoue K, Kawada T, Sugimoto E . Swimming endurance capacity of mice is increased by chronic consumption of mediumchain triglycerides. J Nutr 1995; 125: 531–539.

    CAS  PubMed  Google Scholar 

  60. Van Zyl CG, Lambert EV, Hawley JA, Noakes TD, Dennis SC . Effects of medium-chain triglyceride ingestion on fuel metabolism and cycling performance. J Appl Physiol 1996; 80: 2217–2225.

    Article  CAS  Google Scholar 

  61. Errigo A, Carru C, Pes GM, Deiana L, Franceschi C, Baggio G . Bone metabolism parameters in oldest-old subjects: preliminary findings in the Sardinian Centenarian Study. Biochim Clin 2000; 24: 345.

    Google Scholar 

  62. Mocchegiani E, Giacconi R, Cipriano C, Costarelli L, Muti E, Tesei S et al. Zinc, metallothioneins, and longevity–effect of zinc supplementation: zincage study. Ann NY Acad Sci 2007; 1119: 129–146.

    Article  CAS  Google Scholar 

  63. Gaffney-Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE . Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc 2009; 57: 1073–1079.

    Article  Google Scholar 

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Acknowledgements

We are grateful to Dr Maria Rosaria Manunta of the Sassari University Library for her assistance in retrieving historical documents.

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Authors and Affiliations

  1. Dipartimento di Medicina Clinica e Sperimentale, National Institute of Biostructures and Biosystems, University of Sassari, Sassari, Italy,

    G M Pes, M P Dore, G P Sechi & A Errigo

  2. UO di Endocrinologia, Malattie della Costituzione e della Nutrizione, AOU Sassari, Sassari, Italy,

    F Tolu

  3. Departamento de Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Màlaga, Màlaga, Spain

    A Canelada

  4. IACCHOS, Université catholique de Louvain, Louvain-La-Neuve, Belgium

    M Poulain

  5. Estonian Institute for Population Studies, Tallinn University, Tallinn, Estonia

    M Poulain

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Pes, G., Tolu, F., Dore, M. et al. Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factors. Eur J Clin Nutr 69, 411–418 (2015). https://doi.org/10.1038/ejcn.2014.230

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