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Carbohydrates, glycemic index and diabetes mellitus

Substitution of red meat with legumes in the therapeutic lifestyle change diet based on dietary advice improves cardiometabolic risk factors in overweight type 2 diabetes patients: a cross-over randomized clinical trial

European Journal of Clinical Nutrition volume 69, pages 592–597 (2015)Cite this article

Subjects

Abstract

Background/Objective:

The objective of this study was to determine the effects of substitution of red meat with legumes in the Therapeutic Lifestyle Change (TLC) diet on cardiometabolic risk factors in type 2 diabetes patients based on dietary education.

Subjects/Methods:

This study was a randomized, controlled, cross-over trial. Thirty-one participants (24 women and 7 men; age: 58.1±6.0 years) with type 2 diabetes were randomly assigned to consume a control diet (legume-free TLC diet) and legume-based TLC diet for 8 weeks. Legume-based TLC diet was the same as the control diet, but the legume-based TLC group was advised to replace two servings of red meat with legumes, 3 days per week. After the interventional period, a washout period was conducted for 4 weeks. The groups were then advised to follow the alternate treatment for 8 weeks. Cardiometabolic risk factors were measured.

Results:

Compared with the legume-free TLC diet, the legume-based TLC diet significantly decreased fasting blood glucose (P=0.04), fasting insulin (P=0.04), triglyceride concentrations (P=0.04) and low-density lipoprotein cholesterol (P=0.02). Total cholesterol concentrations decreased after consumption of both TLC diet and legume TLC diet; however, the data did not differ significantly between the two diets. body mass index (BMI), waist circumference, systolic and diastolic blood pressures did not change significantly after consumption of either the legume-free TLC diet or the legume-based TLC diet.

Conclusions:

Dietary advice given for substitution of red meat with legume intakes within a TLC diet-improved lipid profiles and glycemic control among diabetes patients, which were independent from BMI change. This trial was registered in the Iranian Registry of Clinical Trials (http://www.irct.ir) as IRCT201202251640N7.

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Acknowledgements

The authors acknowledge Ms N Shiva for critical editing of English grammar and syntax of the manuscript. This study was funded by grant no. 411 from the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Author Contributions

The project idea for this study was from S.H. The project was designed by P.M, S.H and F.A. S.H, and M.H analyzed and interpreted the data; S.H and P.M prepared the manuscript. All authors read and approved the final manuscript. Overall F.A supervised the project and approved the final version of the manuscript to be submitted.

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Authors and Affiliations

  1. Nutrition and Endocrine Research center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    S Hosseinpour-Niazi

  2. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    S Hosseinpour-Niazi

  3. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    P Mirmiran

  4. Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    M Hedayati

  5. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    F Azizi

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  1. S Hosseinpour-Niazi
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Corresponding author

Correspondence to P Mirmiran.

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Hosseinpour-Niazi, S., Mirmiran, P., Hedayati, M. et al. Substitution of red meat with legumes in the therapeutic lifestyle change diet based on dietary advice improves cardiometabolic risk factors in overweight type 2 diabetes patients: a cross-over randomized clinical trial. Eur J Clin Nutr 69, 592–597 (2015). https://doi.org/10.1038/ejcn.2014.228

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  • DOI: https://doi.org/10.1038/ejcn.2014.228

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