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Interventions and public health nutrition

Effects of a large-scale micronutrient powder and young child feeding education program on the micronutrient status of children 6–24 months of age in the Kyrgyz Republic

Abstract

Background/Objectives:

To combat iron and other micronutrient deficiencies, the Ministry of Health of the Kyrgyz Republic launched a regional Infant and Young Child Nutrition (IYCN) program in 2009, which included promotion of home fortification with micronutrient powder (MNP) containing iron (12.5 mg elemental iron), vitamin A (300 μg) and other micronutrients. Every 2 months children aged 6–24 months were provided 30 sachets to be taken on a flexible schedule. The objective was to assess biochemical indicators of iron and vitamin A status among children aged 6–24 months at the baseline and follow-up surveys.

Subjects/Methods:

Cross-sectional representative cluster surveys were conducted in 2008 (n=571 children) and 2010 (n=541). Data collected included measurement of hemoglobin, serum ferritin, soluble transferrin receptor (sTfR), retinol-binding protein, C-reactive protein (CRP) and α1-glycoprotein acid (AGP).

Results:

Among all children, declines were observed in the prevalence of: anemia, 50.6% versus 43.8% (P=0.05); total iron deficiency (either low ferritin or high sTfR), 77.3% versus 63.7% (P<0.01); and iron deficiency anemia, 45.5% versus 33.4% (P<0.01). Among children without inflammation as measured by CRP and AGP, similar declines were observed, but only declines in total iron deficiency and iron deficiency anemia reached statistical significance. Among all children and those without inflammation, the prevalence of vitamin A deficiency remained the same.

Conclusions:

One year after the introduction of home fortification with MNP, within a larger IYCN program, the prevalence of anemia, iron deficiency and iron deficiency anemia declined, but vitamin A deficiency remained unchanged.

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References

  1. Institute of Obstetrics and Pediatrics [Kyrgyz Republic], Macro International Inc. Kyrgyz Republic, Demographic and Health Survey 1997. Research Institute of Obstetrics and Pediatrics, Ministry of Health of the Kyrgyz Republic and Macro International Inc: Calverton, Maryland, USA, 1998.

  2. Lundeen E, Schueth T, Toktobaev N, Zlotkin S, Hyder SM, Houser R . Daily use of Sprinkles micronutrient powder for 2 months reduces anemia among children 6 to 36 months of age in the Kyrgyz Republic: a cluster-randomized trial. Food Nutr Bull 2010; 31: 446–460.

    Article  Google Scholar 

  3. Dewey KG, Adu-Afarwuah S . Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Matern Child Nutr 2008; 4: 24–85.

    Article  Google Scholar 

  4. De-Regil LM, Suchdev PS, Vist GE, Walleser S, Pena-Rosas JP . Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst Rev 2011; 9, CD008959.

  5. World Health Organization. Guideline: Use of Multiple Micronutrient Powders for Home Fortification of Foods Consumed by Infants and Children 6–23 Months of Age. World Health Organization: Geneva, 2011.

  6. Ndemwa P, Klotz CL, Mwaniki D, Sun K, Muniu E, Andango P et al. Relationship of the availability of micronutrient powder with iron status and hemoglobin among women and children in the Kakuma Refugee Camp, Kenya. Food Nutr Bull 2011; 32: 286–291.

    Article  Google Scholar 

  7. Bilukha O, Howard C, Wilkinson C, Bamrah S, Husain F . Effects of multimicronutrient home fortification on anemia and growth in Bhutanese refugee children. Food Nutr Bull 2011; 32: 264–276.

    Article  Google Scholar 

  8. Menon P, Ruel MT, Loechl CU, Arimond M, Habicht JP, Pelto G et al. Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti. J Nutr 2007; 137: 1023–1030.

    Article  CAS  Google Scholar 

  9. Jack SJ, Ou K, Chea M, Chhin L, Devenish R, Dunbar M et al. Effect of micronutrient sprinkles on reducing anemia: a cluster-randomized effectiveness trial. Arch Pediatr Adolesc Med 2012; 166: 842–850.

    Article  Google Scholar 

  10. Thurnham DI, McCabe GP, Northrop-Clewes CA, Nestel P . Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis. Lancet 2003; 362: 2052–2058.

    Article  CAS  Google Scholar 

  11. Thurnham DI, McCabe LD, Haldar S, Wieringa FT, Northrop-Clewes CA, McCabe GP . Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr 2010; 92: 546–555.

    Article  CAS  Google Scholar 

  12. de Pee S, Kraemer K, van den Briel T, Boy E, Grasset C, Moench-Pfanner R et al. Quality criteria for micronutrient powder products: report of a meeting organized by the World Food Programme and Sprinkles Global Health Initiative. Food Nutr Bull 2008; 29: 232–241.

    Article  Google Scholar 

  13. Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE . Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr 2004; 134: 3127–3132.

    Article  CAS  Google Scholar 

  14. World Health Organization, United Nations University, UNICEF. Iron deficiency anemia assessment, prevention, and control- a guide for programme managers. World Health Organization: Geneva, 2001.

  15. Gorstein JL, Dary O, Pongtorn, Shell-Duncan B, Quick T, Wasanwisut E . Feasibility of using retinol-binding protein from capillary blood specimens to estimate serum retinol concentrations and the prevalence of vitamin A deficiency in low-resource settings. Public Health Nutr 2008; 11: 513–520.

    Article  Google Scholar 

  16. Zlotkin S . More proof that home fortification is of value in children with iron deficiency anemia. Arch Pediatr Adolesc Med 2012; 166: 869–870.

    Article  Google Scholar 

  17. Zlotkin S, Antwi KY, Schauer C, Yeung G . Use of microencapsulated iron(II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk. Bull World Health Org 2003; 81: 108–115.

    PubMed  Google Scholar 

  18. Smuts CM, Dhansay MA, Faber M, van Stuijvenberg ME, Swanevelder S, Gross R et al. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants. J Nutr 2005; 135: 653S–659S.

    Article  CAS  Google Scholar 

  19. Tanumihardjo SA . Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr 2011; 94: 658S–665S.

    Article  Google Scholar 

  20. Ortiz I, Chai J, Cummins M . Escalating Food Prices: The Threat to Poor Households and Policies to Safeguard a Recovery for All. UNICEF: New York, 2011.

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Acknowledgements

Both surveys were administered under a cooperative agreement between UNICEF and the Centers for Disease Control and Prevention (CDC). The surveys were carried out with support from the Central and Eastern Europe/Commonwealth of Independent States UNICEF regional office and the Swiss Red Cross. The collaborating partners included the Ministry of Health of the Kyrgyz Republic (MOH), the National Statistical Committee of the Kyrgyz Republic (NSC), the Talas Oblast Regional Statistics Department and the United Nations Children’s Fund (UNICEF)-Kyrgyz Republic country office.

Disclaimer

The findings and conclusions of this report do not necessarily represent the official position of the US Centers for Disease Control and Prevention.

Use of trade names is for identification only and does not imply endorsement by the US Department of Health and Human Services.

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Correspondence to M K Serdula.

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Appendix

Appendix

The Kyrgyz Republic Working Group:

G Samohleb1, R Donnie Whitehead Jr2, U Mandava, KM Sullivan3,4

1Kyrgyz Republic Department of Statistics, Bishkek, Kyrgyz Republic; 2 Division of Laboratory Sciences, CDC, Atlanta, GA, USA; 3Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA; 4Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA Deceased.

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Serdula, M., Lundeen, E., Nichols, E. et al. Effects of a large-scale micronutrient powder and young child feeding education program on the micronutrient status of children 6–24 months of age in the Kyrgyz Republic. Eur J Clin Nutr 67, 703–707 (2013). https://doi.org/10.1038/ejcn.2013.67

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