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Current issues in determining dietary protein and amino-acid requirements

European Journal of Clinical Nutrition volume 68, pages 285–286 (2014)Cite this article

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Abstract

Pregnancy and the first two years of life are periods of rapid growth and yet the knowledge of requirements for protein and dietary indispensable amino acids is very limited. The development of carbon oxidation methods opens the way to studies that should fill these important gaps in knowledge.

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References

  1. WHO. Protein and amino acid requirements in human nutrition. WHO Technical Report Series 935. Geneva, 2007.

  2. Pencharz PB, Ball RO . Different approaches to define individual amino acid requirements. Annu Rev Nutr 2003; 23: 101–116.

    Article  CAS  Google Scholar 

  3. Kurpad AV, Regan MM, Raj TD, Rao VN, Gnanou J, Young VR . The daily phenylalanine requirement of healthy Indian adults. Am J Clin Nutr 2006; 83: 1331–1336.

    Article  CAS  Google Scholar 

  4. Kurpad AV, Raj T, El-Khoury AE, Beaumier L, Kuriyan R, Srivatsa A et al. Daily requirement for and splanchnic uptake of leucine in healthy adult Indians. Am J Clin Nutr 2001; 74: 747–755.

    Article  CAS  Google Scholar 

  5. Elango R, Ball RO, Pencharz PB . Indicator amino acid oxidation: concept and application. J Nutr 2008; 138: 243–246.

    Article  CAS  Google Scholar 

  6. Pillai RR, Elango R, Muthayya S, Ball RO, Kurpad AV, Pencharz PB . Lysine requirement of healthy Indian school-aged children determined by the indicator amino acid oxidation technique. J Nutr 2010; 140: 54–59.

    Article  CAS  Google Scholar 

  7. Humayun MA, Elango R, Ball RO, Pencharz PB . A re-evaluation of protein requirement in young men using the indicator amino acid oxidation technique. Am J Clin Nutr 2007; 86: 995–1002.

    Article  CAS  Google Scholar 

  8. Young VR, Bier DM, Pellett PL . A theoretical basis for increasing current estimates of the amino acid requirements in adult man with experimental support. Am J Clin Nutr 1989; 50: 80–92.

    Article  CAS  Google Scholar 

  9. Jackson AA, Gibson NR, Jahoor F . Synthesis of erythrocyte glutathione in healthy adults consuming a safe amount of dietary protein. Am J Clin Nutr 2004; 80: 101–107.

    Article  CAS  Google Scholar 

  10. Elango R, Ball RO, Pencharz PB . Recent advances in protein and amino acid requirements. Br J Nutr 2012; 108: S22–S30.

    Article  CAS  Google Scholar 

  11. Dubois S, Coulombe C, Pencharz P, Pinsonneault O, Duquette MP . Ability of the Higgins Nutrition Intervention Program to improve adolescent pregnancy outcome. J Am Diet Assoc 1997; 97: 871–878.

    Article  CAS  Google Scholar 

  12. Ziegler EE, O'Donnell AM, Nelson SE, Fomon SJ . Body composition of the reference fetus. Growth 1976; 40: 329–341.

    CAS  PubMed  Google Scholar 

  13. Higgins AC, Moxley JE, Pencharz PB, Mikolainis D, Dubois S . Impact of the Higgins Nutrition Intervention Program on birthweight: a within-mother analysis. J Am Diet Assoc 1989; 89: 1097–1103.

    CAS  PubMed  Google Scholar 

  14. Koletzko B, von Kries R, Monasterolo RC, Subías JE, Scaglioni S, Giovannini M et alEuropean Childhood Obesity Trial Study Group. Infant feeding and later obesity risk. Adv Exp Med Biol 2009; 646: 15–29.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Nutrition and Hepatology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada

    P Pencharz

  2. US Department of Agriculture, Children's Nutrition Research Center, Agricultural Research Service, Houston, TX, USA

    F Jahoor

  3. St John’s Medical College, Bangalore, Karnataka, India

    A Kurpad

  4. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark

    K F Michaelsen

  5. Division of Human Health, IAEA, Nutritional and Health-related Environmental Studies Section, Vienna, Austria

    C Slater

  6. AgroParisTech, UMR0914 Nutrition Physiology and Ingestive Behavior, Paris, France

    D Tomé

  7. Viale delle Ginestre 8, Ariccia (RM), Italy

    R Weisell

Authors
  1. P Pencharz
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  2. F Jahoor
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  3. A Kurpad
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  4. K F Michaelsen
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  5. C Slater
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  6. D Tomé
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  7. R Weisell
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Corresponding author

Correspondence to P Pencharz.

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The authors declare no conflict of interest.

Additional information

This commentary is based on discussions during a Consultants’ Meeting at the International Atomic Energy Agency, Vienna, 12–14 November 2013.

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Pencharz, P., Jahoor, F., Kurpad, A. et al. Current issues in determining dietary protein and amino-acid requirements. Eur J Clin Nutr 68, 285–286 (2014). https://doi.org/10.1038/ejcn.2013.297

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