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Body composition, energy expenditure and physical activity

The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake

Abstract

Background/objectives:

A decline in resting energy expenditure (REE) beyond that predicted from changes in body composition has been noted following dietary-induced weight loss. However, it is unknown whether a compensatory downregulation in REE also accompanies exercise (EX)-induced weight loss, or whether this adaptive metabolic response influences energy intake (EI).

Subjects/methods:

Thirty overweight and obese women (body mass index (BMI)=30.6±3.6 kg/m2) completed 12 weeks of supervised aerobic EX. Body composition, metabolism, EI and metabolic-related hormones were measured at baseline, week 6 and post intervention. The metabolic adaptation (MA), that is, difference between predicted and measured REE was also calculated post intervention (MApost), with REE predicted using a regression equation generated in an independent sample of 66 overweight and obese women (BMI=31.0±3.9 kg/m2).

Results:

Although mean predicted and measured REE did not differ post intervention, 43% of participants experienced a greater-than-expected decline in REE (−102.9±77.5 kcal per day). MApost was associated with the change in leptin (r=0.47; P=0.04), and the change in resting fat (r=0.52; P=0.01) and carbohydrate oxidation (r=−0.44; P=0.02). Furthermore, MApost was also associated with the change in EI following EX (r=−0.44; P=0.01).

Conclusions:

Marked variability existed in the adaptive metabolic response to EX. Importantly, those who experienced a downregulation in REE also experienced an upregulation in EI, indicating that the adaptive metabolic response to EX influences both physiological and behavioural components of energy balance.

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References

  1. Schwartz A, Doucet É . Relative changes in resting energy expenditure during weight loss: a systematic review. Obes Rev 2010; 11: 531–547.

    CAS  Article  Google Scholar 

  2. Tremblay A, Royer M, Chaput J, Doucet E . Adaptive thermogenesis can make a difference in the ability of obese individuals to lose body weight. Int J Obes 2013; 37: 759–764.

    CAS  Article  Google Scholar 

  3. Major G, Doucet E, Trayhurn P, Astrup A, Tremblay A . Clinical significance of adaptive thermogenesis. Int J Obes 2007; 31: 204–212.

    CAS  Article  Google Scholar 

  4. Dulloo A, Jacquet J, Montani JP, Schutz Y . Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity? Obes Rev 2012; 13: 105–121.

    Article  Google Scholar 

  5. Byrne NM, Wood R, Schutz Y, Hills AP . Does metabolic compensation explain the majority of less-than-expected weight loss in obese adults during a short-term severe diet and exercise intervention. Int J Obes 2012; 36: 1472–1478.

    CAS  Article  Google Scholar 

  6. Flatt J . Exaggerated claim about adaptive thermogenesis. Int J Obes 2007; 31: 1626.

    CAS  Article  Google Scholar 

  7. Schwartz A, Kuk JL, Lamothe G, Doucet E . Greater than predicted decrease in resting energy expenditure and weight loss: results from a systematic review. Obesity 2012; 20: 2307–2310.

    Article  Google Scholar 

  8. Heilbronn L, de Jonge L, Frisard M, DeLany J, Larson-Meyer D, Rood J et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006; 295: 1539–1548.

    CAS  Article  Google Scholar 

  9. Johannsen DL, Knuth ND, Huizenga R, Rood JC, Ravussin E, Hall KD . Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab 2012; 97: 2489–2496.

    CAS  Article  Google Scholar 

  10. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL . Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 2002; 87: 2391–2397.

    CAS  Article  Google Scholar 

  11. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579.

    CAS  Article  Google Scholar 

  12. Peronnet F, Massicotte D . Table of nonprotein respiratory quotient: an update. Can J Sport Sci 1991; 16: 23–29.

    CAS  PubMed  Google Scholar 

  13. Compher C, Frankenfield D, Keim N, Roth-Yousey L . Best practice methods to apply to measurement of resting metabolic rate in adults: a systematic review. J Am Diet Assoc 2006; 106: 881–903.

    Article  Google Scholar 

  14. Weir JBV . New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949; 109: 1–9.

    Article  Google Scholar 

  15. Achten J, Jeukendrup AE . Maximal fat oxidation during exercise in trained men. Int J Sports Med 2003; 24: 603–608.

    CAS  Article  Google Scholar 

  16. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R . Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.

    CAS  Article  Google Scholar 

  17. Caudwell P, Finlayson G, Gibbons C, Hopkins M, King N, Naslund E et al. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am J Clin Nutr 2013; 97: 7–14.

    CAS  Article  Google Scholar 

  18. Johnstone AM, Murison SD, Duncan JS, Rance KA, Speakman JR . Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. Am J Clin Nutr 2005; 82: 941–948.

    CAS  Article  Google Scholar 

  19. King NA, Hopkins M, Caudwell P, Stubbs R, Blundell JE . Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss. Int J Obes 2008; 32: 177–184.

    CAS  Article  Google Scholar 

  20. Barwell N, Malkova D, Leggate M, Gill J . Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism 2009; 58: 1320–1328.

    CAS  Article  Google Scholar 

  21. Church TS, Martin CK, Thompson AM, Earnest CP, Mikus CR, Blair SN . Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PLoS One 2009; 4: e4515.

    Article  Google Scholar 

  22. Lecoultre V, Ravussin E, Redman LM . The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms. J Clin Endocrinol Metab 2011; 96: E1512–E1516.

    CAS  Article  Google Scholar 

  23. Doucet E, Pierre SS, Alméras N, Mauriège P, Richard D, Tremblay A . Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab 2000; 85: 1550–1556.

    CAS  PubMed  Google Scholar 

  24. Snitker Sr, Pratley RE, Nicolson M, Tataranni PA, Ravussin E . Relationship between muscle sympathetic nerve activity and plasma leptin concentration. Obes Res 1997; 5: 338–340.

    CAS  Article  Google Scholar 

  25. Rosenbaum M, Kissileff HR, Mayer LES, Hirsch J, Leibel RL . Energy intake in weight-reduced humans. Brain Res 2010; 1350: 95–102.

    CAS  Article  Google Scholar 

  26. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba B, Raz I, Saad M et al. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physio- Endoc M. 1990; 259: E650–E657.

    CAS  Google Scholar 

  27. Seidell J, Muller D, Sorkin J, Andres R . Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes Relat Metab Disord 1992; 16: 667–674.

    CAS  PubMed  Google Scholar 

  28. Marra M, Scalfi L, Covino A, Esposito-Del Puente A, Contaldo F . Fasting respiratory quotient as a predictor of weight changes in non-obese women. Int J Obes Relat Metab Disord 1998; 22: 601–603.

    CAS  Article  Google Scholar 

  29. Baak Mv . The peripheral sympathetic nervous system in human obesity. Obes Rev 2001; 2: 3–14.

    Article  Google Scholar 

  30. Rosenbaum M, Hirsch J, Gallagher D, Leibel R . Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 2008; 88: 906–912.

    CAS  Article  Google Scholar 

  31. Kissileff HR, Thornton JC, Torres MI, Pavlovich K, Mayer LS, Kalari V et al. Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr 2012; 95: 309–317.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

This research was supported by BBSRC grant numbers BBS/B/05079 and BB/G005524/1 (DRINC), EU FP7 Full4Health (266408) and the Stockholm county council (ALF).

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Correspondence to M Hopkins.

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Hopkins, M., Gibbons, C., Caudwell, P. et al. The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake. Eur J Clin Nutr 68, 581–586 (2014). https://doi.org/10.1038/ejcn.2013.277

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  • DOI: https://doi.org/10.1038/ejcn.2013.277

Keywords

  • exercise-induced weight loss
  • energy intake
  • resting energy expenditure
  • leptin

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