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Total body potassium revisited

European Journal of Clinical Nutrition volume 68, pages 153–154 (2014)Cite this article

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There are a multitude of methods available today that can be used to assess body composition in humans, from pre-term infants to the oldest adults. A body composition method is usually focused at a specific component of body composition, such as fat mass, total body water (TBW) or body cell mass (BCM). Many methods have been developed over the past century, with one of the earliest measures of body composition being total body potassium counting (TBK), which was first recognized in 1950s. There were a large number of whole body counters (WBC) available in 1970s,1 but over time the use of TBK facilities has decreased and old counters have been decommissioned. With other more accessible body composition technologies becoming more commonplace, today TBK is a rarely utilized method. However, as no alternative technology provides a direct and precise measure of BCM,2 the need for accurate body composition techniques for clinical and public health demands that TBK counting as a method should be revisited.

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References

  1. International Atomic Energy Agency. Directory of Whole-Body Radioactivity Monitors. IAEA: Vienna, Austria, 1970.

  2. Ellis KJ . Body potassium: the reference method for body cell mass. In:Pierson Jr RN (ed) Quality of the Body Cell Mass: Body Composition in the Third Millennium. Springer: New York, NY, USA, 2000, pp 119–129.

    Chapter  Google Scholar 

  3. Moore FD, Olesen KH, McMurray JD, Parker HV, Ball MR, Boyden CM . The Body Cell Mass and its Supporting Environment. W.B. Saunders Company: Philadelphia, PA, USA; London, UK, 1963.

    Google Scholar 

  4. Preston T, Fearon KCH, Robertson I, East BW, Calman KC . Tissue loss during severe wasting in lung cancer patients. In:Ellis KJ, Yasumura S, Morgan WP (eds) In Vivo Body Composition Studies. IPSM: London, UK, 1987, pp 60–69.

    Google Scholar 

  5. Flynn MA, Woodruff C, Clark J, Chase G . Total body potassium in normal children. Pediatr Res 1972; 6: 239–245.

    Article  CAS  Google Scholar 

  6. Murphy AJ, Davies PSW . Body cell mass index in children: interpretation of total body potassium results. Br J Nutr 2008; 100: 666–668.

    Article  CAS  Google Scholar 

  7. Wang Z, Heshka S, Wang J, Heymsfield S . Body cell mass: validation of total body potassium prediction model in children and adolescents. Int J Body Comp Res 2005; 3: 153–158.

    Google Scholar 

  8. Wang Z, Deurenberg P, Wang W, Pietrobelli A, Baumgartner RN, Heymsfield SB . Hydration of fat-free body mass: new physiological modeling approach. Am J Physiol 1999; 276: E995–E1003.

    Article  CAS  Google Scholar 

  9. Wang Z, Zhu A, Wang J, Pierson RN, Heymsfield SB . Whole-body skeletal muscle mass: development and validation of total-body potassium prediction models. Am J Clin Nutr 2003; 77: 76–82.

    Article  CAS  Google Scholar 

  10. Wang Z, Heshka S, Wang J, Heymsfield SB . Total body protein mass: validation of total body potassium prediction model in children and adolescents. J Nutr 2006; 136: 1032–1036.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Children’s Nutrition Research Centre, Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia

    A J Murphy

  2. Department of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA

    K J Ellis

  3. Department of Physiology, St. John’s Medical College, Bangalore, India

    A V Kurpad

  4. Stable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, Glasgow, UK

    T Preston

  5. Division of Human Health, Nutritional and Health-related Environmental Studies Section, International Atomic Energy Agency, Vienna, Austria

    C Slater

Authors
  1. A J Murphy
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  2. K J Ellis
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  3. A V Kurpad
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  4. T Preston
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  5. C Slater
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Corresponding author

Correspondence to A J Murphy.

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The authors declare no conflict of interest.

Additional information

This commentary is based on discussions during a Consultants' Meeting at the International Atomic Energy Agency, Vienna, 17–19 July 2013.

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Murphy, A., Ellis, K., Kurpad, A. et al. Total body potassium revisited. Eur J Clin Nutr 68, 153–154 (2014). https://doi.org/10.1038/ejcn.2013.262

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