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Lipids and cardiovascular/metabolic health

Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial



Most patients with Type 2 diabetes mellitus(DM) also have metabolic syndrome (MetS), which is associated with an increased risk of coronary heart disease prevalence. Limited information is available on the effect and effective doses of oat intake with a structured dietary intervention in metabolic control and cardiovascular disease (CVD) risk prevention with the population who has Type 2 DM and meets the MetS criteria.


A total of 260 Type 2 DM patients meeting MetS National Cholesterol Education Program Adult Treatment Panel III criteria were selected from 445 patients between 50 and 65 years of age, and they participated in a single-blinded, 30-day centralized management of a dietary program in China. Participants in the program were randomly assigned into one of the four groups: usual care group (control group, only basic health advice), diet group (systematic diet plans and intensive education), 50 g-organic naked oat with whole germ group (ONOG) and 100 g-organic naked oat with whole germ group (daily ONOG replacement boiled into porridge based on diet group). The primary outcomes were the relative changes in glycosylated hemoglobin (HbA1c) and insulin resistance after a 30-day intervention among the four groups.


HbA1c decreased significantly with the increase in interventions (Ptrend<0.05). Similar results were also obtained in plasma glucose, serum lipid and hypersensitive C-reactive protein (hs-CRP). For the 100 g-ONOG group but not 50 g-ONOG group, HbA1c and hs-CRP reduced significantly by 0.51% and 1.29 mg/l (P<0.05, vs diet group), respectively. The 100 g-ONOG group showed a reduction by 0.22 U*mol/l2 in insulin resistance, compared with the 50 g-ONOG group (P=0.039).


Compared with diet alone or no diet, 50–100 g/day ONOG supplement to structured dietary intervention, at a dose of 100 g/day especially, contributes to the Type 2 DM patients meeting MetS criteria in their metabolic control and CVD risk prevention, with external factors being controlled.

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We thank the Beijing Nutrition Society and the Inner Mongolia Medical College, Third Hospital for their help with the study. We also thank the members of our volunteer team, Zhi Sun, Bin Cai, Fang Li, Guangling Hu, Hao Yu, Jianqin Chen, Junguo He, Meihong Yang, Peng Song, Peng Zhang, Xiping Xu, Yao Meng, Meiyan Liu, Yuxia Jin, Ying Li, Yaohui Jiang, Ya Zhang and Zhibin Sun for their excellent job with the study. We thank Yimin Zhu, Yongliang Zhang, Shuhua Zhao and Chuan Fan, Dewei Liang for editing the manuscript for English. This study was funded by Inner Mongolia Sanzhuliang Natural Oats Industry Corporation. The trial is registered at, number NCT01495052. The sponsor of the study had no role in the study design, data collection, data analysis, data interpretation or writing of the report.

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Correspondence to Y Li.

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The authors’ responsibilities were described as follows: XM participated in the research design, conducted the research, performed the statistical analysis and wrote the manuscript; YL designed the research and had primary responsibility for final content. All authors participated in data acquisition and study supervision. All authors approved the final version of the report.

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Ma, X., Gu, J., Zhang, Z. et al. Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial. Eur J Clin Nutr 67, 1291–1297 (2013).

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  • cardiovascular disease
  • cereals
  • diabetes mellitus, Type 2
  • Metabolic syndrome X

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