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Delirium as a result of vitamin B12 deficiency in a vegetarian female patient

Abstract

Vitamin B12 deficiency can manifest with haematological, gastrointestinal and neuropsychiatric signs. The neuropsychiatric symptoms may be concurrent or precede the other symptoms. The reported case is a clinical case of delirium due to vitamin B12 deficiency in a female vegetarian patient. The patient was treated with vitamin B12 supplementation. Initially, it was difficult to diagnose this patient, who presented with delirium that could have been due to multiple causes. The finding underlines the importance of conducting a complete laboratory test panel for delirium, including the blood levels of vitamin B12.

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References

  1. Gutierrez M, Franques J, Faivre A, Koric L, Chiche L, Attarian S et al. Diagnosis of vitamin B12 deficiency: a case illustrating diagnostic pitfalls. Rev Neurol (Paris) 2010; 166: 242–247.

    Article  CAS  Google Scholar 

  2. Tufan AE, Bilici R, Usta G, Erdoğan A . Mood disorder with mixed, psychotic features due to vitamin B12 deficiency in an adolescent: case report. Child Adolesc Psychiatry Ment Health 2012; 6: 25.

    Article  Google Scholar 

  3. Catalano G, Catalano MC, Rosenberg EI, Embi PJ, Embi CS . Catatonia: another neuropsychiatric presentation of vitamin B12 deficiency? Psychosomatics 1998; 39: 456–460.

    Article  CAS  Google Scholar 

  4. Berry N, Sagar R, Tripathi BM . Catatonia and other psychiatric symptoms with vitamin B12 deficiency. Acta Psychiatr Scand 2003; 108: 156–159.

    Article  CAS  Google Scholar 

  5. Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP . Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry 2000; 157: 715–721.

    Article  CAS  Google Scholar 

  6. Andrès E, Vogel T, Federici L, Zimmer J, Ciobanu E, Kaltenbach G . Cobalamin deficiency in elderly patients: a personal view. Curr Gerontol Geriatr Res 2008; 2008, 848267.

  7. Sadock BJ, Sadock VA . Kaplan and Sadock’s Synopsis of Psychiatry 10th edn. Lippincott Williams & Wilkins, 2007, pp 323–329.

    Google Scholar 

  8. Machado-Vieira R, Salvadore G, Diazgranados N, Zarate CA Jr . Ketamine and the next generation of antidepressants with a rapid onset of action. Pharmacol Ther 2009; 123: 143–150.

    Article  CAS  Google Scholar 

  9. Kwok T, Lee J, Lam L, Woo J . Vitamin B12 supplementation did not improve cognition but reduced delirium in demented patients with vitamin B12 deficiency. Arch of Gerontol Geriatr 2008; 46: 273–282.

    Article  CAS  Google Scholar 

  10. Harrington AL, Dixon TM, Ho CH . Vitamin B12 deficiency as a cause of delirium in a patient with spinal cord injury. Arch Phys Med Rehabil 2011; 92: 1917–1920.

    Article  Google Scholar 

Download references

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Correspondence to O Sentissi.

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Mavrommati, K., Sentissi, O. Delirium as a result of vitamin B12 deficiency in a vegetarian female patient. Eur J Clin Nutr 67, 996–997 (2013). https://doi.org/10.1038/ejcn.2013.128

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  • DOI: https://doi.org/10.1038/ejcn.2013.128

Keywords

  • delirium
  • vitamin B12 deficiency
  • vegetarian

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