Table 3 Odds ratios (ORs) and 95% confidence interval (CI) for colorectal, rectum and colon cancer risk with rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms

From: Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Variants Colorectal Rectum Colon
  Case/control OR 95% CI Case/control OR 95% CI Case/control OR 95% CI
rs1229984 (ADH1B)          
 G/G 1129/1800 1 429/651 1 700/1149 1
 G/A 97/176 0.95 0.72–1.24 30/66 0.77 0.48–1.21 67/110 1.07 0.77–1.49
 A/A 5/6 1.36 0.41–4.53 2/— 3/6 0.86 0.21–3.50
P-valuea    0.81    0.52    0.89
rs1573496 (ADH7)          
 G/G 947/1549 1 337/543 1 610/1,006 1
 C/G 205/311 1.09 0.90–1.32 79/110 1.17 0.85–1.61 126/201 1.04 0.81–1.32
 C/C 13/19 1.30 0.64–2.64 6/5 2.73 0.78–9.57 7/14 0.87 0.35–2.18
P-valuea    0.55    0.19    0.91
rs441 (ALDH2)          
 T/T 794/1273 1 288/458 1 506/815 1
 T/C 358/604 0.95 0.81–1.12 134/204 1.06 0.80–1.38 224/400 0.90 0.73–1.10
 C/C 30/70 0.67 0.43–1.05 12/27 0.71 0.35–1.43 18/43 0.65 0.37–1.14
P-valuea    0.20    0.56    0.22
  1. aP-value for difference in risk between heterozygous and rare homozygous compared with wild-type individuals, determined with a Wald test according to a χ2-distribution with 2 d.f.