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Carbohydrates, glycemic index and diabetes mellitus

Soups increase satiety through delayed gastric emptying yet increased glycaemic response



Previous studies have demonstrated the satiating properties of soups compared with solids; however, the mechanisms controlling soup-induced satiety are unknown. This study aimed to understand the physiological mechanisms causing soup to be more satiating.


A total of 12 volunteers were tested on three occasions after a solid meal, chunky soup or smooth soup test meal for gastric emptying (GE) using the sodium [1-13C] acetate breath test, satiety using visual analog scales (VAS) and glycaemic response (GR) using finger prick blood samples.


There was a significant difference in GE half-time (P=0.022) and GE ascension time (P=0.018), with the longest GE times for the smooth soup and the shortest for the solid meal. The GR area under the curve was significantly different between meals (P=0.040). The smooth soup had the greatest GR (87.0±49.5 mmol/l/min), followed by the chunky soup (65.4±48.0 mmol/l/min), with the solid meal having the lowest GR (61.6±36.8 mmol/l/min). Volunteers were fuller after the smooth soup compared with solid meal (P=0.034).


The smooth soup induced greater fullness compared with the solid meal because of a combination of delayed GE leading to feelings of gastric distension and rapid accessibility of nutrients causing a greater glycaemic response.

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  1. National Centre for Social Research and University College London. Department of Epidemiology and Public Health. Health Survey for England. UK Data Archive [distributor]: Colchester, Essex, 2009.

  2. Himaya A, Louis-Sylvestre J . The effect of soup on satiation. Appetite 1998; 30: 199–210.

    CAS  Article  Google Scholar 

  3. Ranawana DV, Henry CJ . Are caloric beverages compensated for in the short-term by young adults? An investigation with particular focus on gender differences. Appetite 2010; 55: 137–146.

    CAS  Article  Google Scholar 

  4. de Wijk RA, Zijlstra N, Mars M, de Graaf C, Prinz JF . The effects of food viscosity on bite size, bite effort and food intake. Physiol Behav 2008; 95: 527–532.

    CAS  Article  Google Scholar 

  5. de Graaf C . Why liquid energy results in overconsumption. Proc Nutr Soc 2011; 70: 162–170.

    Article  Google Scholar 

  6. Cassady BA, Considine RV, Mattes RD . Beverage consumption, appetite, and energy intake: what did you expect? Am J Clin Nutr 2012; 95: 587–593.

    CAS  Article  Google Scholar 

  7. Cecil JE, Francis J, Read NW . Comparison of the effects of a high-fat and high-carbohydrate soup delivered orally and intragastrically on gastric emptying, appetite, and eating behaviour. Physiol Behav 1999; 67: 299–306.

    CAS  Article  Google Scholar 

  8. Almiron-Roig E, Chen Y, Drewnowski A . Liquid calories and the failure of satiety: how good is the evidence? Obes Rev 2003; 4: 201–212.

    CAS  Article  Google Scholar 

  9. Geliebter A . Gastric distension and gastric capacity in relation to food intake in humans. Physiol Behav 1988; 44: 665–668.

    CAS  Article  Google Scholar 

  10. Mattes R . Soup and satiety. Physiol Behav 2005; 83: 739–747.

    CAS  Article  Google Scholar 

  11. Moran TH, McHugh PR . Cholecystokinin suppresses food intake by inhibiting gastric emptying. Am J Physiol 1982; 242: R491–R497.

    CAS  PubMed  Google Scholar 

  12. Warren JM, Henry CJ, Simonite V . Low glycemic index breakfasts and reduced food intake in preadolescent children. Pediatrics 2003; 112: e414.

    Article  Google Scholar 

  13. Bornet FR, Jardy-Gennetier AE, Jacquet N, Stowell J . Glycaemic response to foods: impact on satiety and long-term weight regulation. Appetite 2007; 49: 535–553.

    CAS  Article  Google Scholar 

  14. Baecke JA, Burema J, Frijters JE . A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982; 36: 936–942.

    CAS  Article  Google Scholar 

  15. Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G et al. Glycaemic index methodology. Nutr Res Rev 2005; 18: 145–171.

    CAS  Article  Google Scholar 

  16. FAO/WHO. Carbohydrates in Human Nutrition-Report of a Joint FAO/WHO Expert Consultation. Food and Agriculture Organisation: Rome, 1998.

  17. Stork AD, Kemperman H, Erkelens DW, Veneman TF . Comparison of the accuracy of the HemoCue glucose analyzer with the Yellow Springs Instrument glucose oxidase analyzer, particularly in hypoglycemia. Eur J Endocrinol 2005; 153: 275–281.

    CAS  Article  Google Scholar 

  18. Wolever TMS The Glycaemic Index: A Physiological Classification of Dietary Carbohydrate. CABI: Oxfordshire, 2006.

    Book  Google Scholar 

  19. Braden B, Adams S, Duan LP, Orth KH, Maul FD, Lembcke B et al. The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. Gastroenterology 1995; 108: 1048–1055.

    CAS  Article  Google Scholar 

  20. Haycock GB, Schwartz GJ, Wisotsky DH . Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr 1978; 93: 62–66.

    CAS  Article  Google Scholar 

  21. Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993; 104: 1640–1647.

    CAS  Article  Google Scholar 

  22. Jackson SJ, Bluck LJ, Coward WA . Use of isotopically labelled octanoic acid to assess the effect of meal size on gastric emptying. Rapid Commun Mass Spectrom 2004; 18: 1003–1007.

    CAS  Article  Google Scholar 

  23. Schommartz B, Ziegler D, Schadewaldt P . Significance of diagnostic parameters in [13C]octanoic acid gastric emptying breath tests. Isotopes Environ Health Stud 1998; 34: 135–143.

    CAS  Article  Google Scholar 

  24. Clegg M, Shafat A . Energy and macronutrient composition of breakfast affect gastric emptying of lunch and subsequent food intake, satiety and satiation. Appetite 2010; 54: 517–523.

    Article  Google Scholar 

  25. Rolls BJ, Bell EA, Thorwart ML . Water incorporated into a food but not served with a food decreases energy intake in lean women. Am J Clin Nutr 1999; 70: 448–455.

    CAS  Article  Google Scholar 

  26. FAO/WHO. Carbohydrates in human nutrition. Report of a Joint FAO/WHO Expert Consultation. FAO Food Nutr Pap 1998; 66: 1–140.

    Google Scholar 

  27. Flood JE, Rolls BJ . Soup preloads in a variety of forms reduce meal energy intake. Appetite 2007; 49: 626–634.

    Article  Google Scholar 

  28. Kissileff HR, Gruss LP, Thornton J, Jordan HA . The satiating efficiency of foods. Physiol Behav 1984; 32: 319–332.

    CAS  Article  Google Scholar 

  29. Rolls BJ, Fedoroff IC, Guthrie JF, Laster LJ . Foods with different satiating effects in humans. Appetite 1990; 15: 115–126.

    CAS  Article  Google Scholar 

  30. Santangelo A, Peracchi M, Conte D, Fraquelli M, Porrini M . Physical state of meal affects gastric emptying, cholecystokinin release and satiety. Br J Nutr 1998; 80: 521–527.

    CAS  Article  Google Scholar 

  31. Marciani L, Hall N, Pritchard SE, Cox EF, Totman JJ, Lad M et al. Preventing gastric sieving by blending a solid/water meal enhances satiation in healthy humans. J Nutr 2012; 142: 1253–1258.

    CAS  Article  Google Scholar 

  32. Horowitz M, Collins PJ, Cook DJ, Harding PE, Shearman DJ . Abnormalities of gastric emptying in obese patients. Int J Obes 1983; 7: 415–421.

    CAS  PubMed  Google Scholar 

  33. Hutson WR, Wald A . Obesity and weight reduction do not influence gastric emptying and antral motility. Am J Gastroenterol 1993; 88: 1405–1409.

    CAS  PubMed  Google Scholar 

  34. Maddox A, Horowitz M, Wishart J, Collins P . Gastric and oesophageal emptying in obesity. Scand J Gastroenterol 1989; 24: 593–598.

    CAS  Article  Google Scholar 

  35. Moore JG, Christian PE, Coleman RE . Gastric emptying of varying meal weight and composition in man. Evaluation by dual liquid- and solid-phase isotopic method. Dig Dis Sci 1981; 26: 16–22.

    CAS  Article  Google Scholar 

  36. Horowitz M, Edelbroek MA, Wishart JM, Straathof JW . Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects. Diabetologia 1993; 36: 857–862.

    CAS  Article  Google Scholar 

  37. Ranawana V, Clegg ME, Shafat A, Henry CJ . Postmastication digestion factors influence glycemic variability in humans. Nutr Res 2011; 31: 452–459.

    CAS  Article  Google Scholar 

  38. Begg DP, Woods SC . The central insulin system and energy balance. Handb Exp Pharmacol 2012; 209: 111–129.

    CAS  Article  Google Scholar 

  39. Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA . Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 1985; 75: 1144–1152.

    CAS  Article  Google Scholar 

  40. Gutzwiller JP, Goke B, Drewe J, Hildebrand P, Ketterer S, Handschin D et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 1999; 44: 81–86.

    CAS  Article  Google Scholar 

  41. Ludwig DS . The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 2002; 287: 2414–2423.

    CAS  Article  Google Scholar 

  42. Jakobsen MU, Dethlefsen C, Joensen AM, Stegger J, Tjonneland A, Schmidt EB et al. Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index. Am J Clin Nutr 2010; 91: 1764–1768.

    CAS  Article  Google Scholar 

  43. Feinle C, Grundy D, Fried M . Modulation of gastric distension-induced sensations by small intestinal receptors. Am J Physiol Gastrointest Liver Physiol 2001; 280: G51–G57.

    CAS  Article  Google Scholar 

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Correspondence to M E Clegg.

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Clegg, M., Ranawana, V., Shafat, A. et al. Soups increase satiety through delayed gastric emptying yet increased glycaemic response. Eur J Clin Nutr 67, 8–11 (2013).

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  • physical state of food
  • satiety
  • gastric emptying
  • glycaemic response

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