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Relationship of serum retinol-binding protein 4 with weight status and lipid profile among Korean children and adults

Abstract

Background/Objectives:

Although some studies have suggested that retinol-binding protein 4 (RBP4), a fat-derived adipokine, is positively related to overweight and obesity-related disorders, these claims have been disputed. This study investigated relationships between RBP4 level and weight status and metabolic disorders in a Korean population including confounding factors, age and gender.

Subjects/Methods:

From 2005 to 2007, we recruited 570 children and 241 of their parents living in Korean urban areas. We analyzed anthropometrical parameters, blood pressure, lipid profiles, and levels of serum glucose, insulin, leptin and RBP4, and estimated dietary intake based on a self-reported 3-day food diary.

Results:

Levels of RBP4 were high for men (226.2 μg/ml), mid-range among women (143.2 μg/ml) and low among boys and girls (boys 71.4, girls 66.9 μg/ml). After adjusting for age, gender differences among adults were consistently maintained (P<0.0001), and gender differences among children were detected minimally (P=0.05). On the basis of Cole's body mass index cutoff points, the prevalence of overweight among children was 19.3%. The prevalence among adults was 32.0%, based on World Health Organization criteria. Overweight children had higher RBP4 concentrations than normal. Overweight women had higher RBP4 levels than those of normal weight. Higher RBP4 levels were observed among overweight men, but the results were not statistically significant. Triglyceride (TG) levels were significantly correlated with RBP4 in all groups.

Conclusions:

Our results indicate that RBP4 concentrations in a Korean population varied with age, gender and overweight status. TG levels could be strongly correlated with RBP4 concentration.

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References

  • Aeberli I, Biebinger R, Lehmann R, Allemand D, Spinas GA, Zimmermann MB (2007). Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab 92, 4359–4365.

    Article  CAS  Google Scholar 

  • Broch M, Vendrell J, Ricart W, Richart CC, Fernandez-Real JM (2007). Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects. Diab Care 30, 1802–1806.

    Article  CAS  Google Scholar 

  • Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH et al. (2006). Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diab Care 29, 2457–2461.

    Article  CAS  Google Scholar 

  • Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000). Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 1240.

    Article  CAS  Google Scholar 

  • Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC et al. (2003). Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 52, 268–276.

    Article  CAS  Google Scholar 

  • Fernandez-Real JM, Moreno JM, Ricart W (2008). Circulating retinol-binding protein-4 concentration might reflect insulin resistance? Associated iron overload. Diabetes 57, 1918–1925.

    Article  CAS  Google Scholar 

  • Gavi S, Stuart LM, Kelly P, Melendez MM, Mynarcik DC, Gelato MC et al. (2007). Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without Type 2 diabetes. J Clin Endocrinol Metab 92, 1886–1890.

    Article  CAS  Google Scholar 

  • Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC et al. (2008). Influence of age on the association of retinol-binding protein 4 with metabolic syndrome. Obesity 16, 893–895.

    Article  CAS  Google Scholar 

  • Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR et al. (2006). Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 354, 2552–2563.

    Article  CAS  Google Scholar 

  • Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC et al. (2006). Retinol-binding protein 4 in human obesity. Diabetes 55, 2805–2810.

    Article  CAS  Google Scholar 

  • Kahn SE, Hull RL, Utzschneider KM (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840–846.

    Article  CAS  Google Scholar 

  • Kim IK, Kim J, Kang JH, Song J (2008). Serum leptin as a predictor of fatty liver in 7-year-old Korean children. Ann Nutr Metab 53, 109–116.

    Article  CAS  Google Scholar 

  • Lee DC, Lee JW, Im JA (2007a). Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism 56, 327–331.

    Article  CAS  Google Scholar 

  • Lee JW, Im JA, Lee HR, Shim JY, Youn BS, Lee DC (2007b). Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women. Obesity (Siver Spring) 15, 2225–2232.

    Article  CAS  Google Scholar 

  • Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS et al. (2008). Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women. J Clin Endocrinol Metab 93, 2263–2268.

    Article  CAS  Google Scholar 

  • Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB et al. (2007). Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in chinese people. J Clin Endocrinol Metab 92, 4827–4834.

    Article  CAS  Google Scholar 

  • Reinehr T, Stoffel-Wagner B, Roth CL (2008). Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight Loss. J Clin Endocrinol Metab 93, 2287–2293.

    Article  CAS  Google Scholar 

  • Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R et al. (1997). Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 82, 579–584.

    CAS  Google Scholar 

  • Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E et al. (2007). High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diab Care 30, 1173–1178.

    Article  CAS  Google Scholar 

  • Tamori Y, Sakaue H, Kasuga M (2006). RBP4, an unexpected adipokine. Nat Med 12, 30–31.

    Article  CAS  Google Scholar 

  • Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM et al. (2005). Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356–362.

    Article  CAS  Google Scholar 

  • Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ et al. (2007). Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab 92, 2590–2597.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank all the participating schools, children and parents. This study was funded by a grant from the Korea National Institute of Health (4845–300–210, 4845–300–260).

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Correspondence to J Song.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on European Journal of Clinical Nutrition website

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Kim, I., Lee, HJ., Kang, J. et al. Relationship of serum retinol-binding protein 4 with weight status and lipid profile among Korean children and adults. Eur J Clin Nutr 65, 226–233 (2011). https://doi.org/10.1038/ejcn.2010.251

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