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Coffee and endothelial function: a battle between caffeine and antioxidants?

Abstract

Although coffee is largely consumed by adults in Western countries, controversy exists about its impact on the cardiovascular system. We recently demonstrated that caffeinated and decaffeinated espresso coffee have different acute effects on endothelial function in healthy subjects, measured using flow-mediated dilation (FMD) of the brachial artery. In this study, we measured the anti-oxidant capacity of two coffee substances in terms of free stable radical 2,2-diphenyl-1-picryl-hydrazyl 50% inhibition (I50 DPPH). The caffeinated coffee had a slightly higher anti-oxidant capacity than decaffeinated espresso coffee (I50 DPPH: 1.13±0.02 vs 1.30±0.03 μl; P<0.001). We suggest that the unfavourable effects observed after caffeinated coffee ingestion are due to caffeine and that the antioxidant activity is responsible for the increased FMD observed after decaffeinated coffee ingestion. Further clinical and epidemiological studies are needed to understand the chronic effects of coffee consumption on health.

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References

  • Buscemi S, Verga S, Batsis JA, Donatelli M, Tranchina MR, Belmonte S et al. (2010). Acute effects of coffee on endothelial function in healthy subjects. Eur J Clin Nutr 64, 483–489.

    CAS  Article  Google Scholar 

  • Buscemi S, Verga S, Batsis JA, Tranchina MR, Belmonte S, Mattina A et al. (2009). Dose dependent effects of decaffeinated coffee on endothelial function in healthy subjects. Eur J Clin Nutr 63, 1200–1205.

    CAS  Article  Google Scholar 

  • Brand Williams W, Cuvelier ME, Berset C (1995). Use of a free radical method to evaluate antioxidant activity. Lebensm Wiss U Technol 28, 25–30.

    CAS  Article  Google Scholar 

  • Cimino F, Sulfaro V, Trombetta D, Saija A, Tomaino A (2007). Radical-scavenging capacity of several Italian red wines. Food Chem 103, 75–81.

    CAS  Article  Google Scholar 

  • Giovanelli G (2005). Evaluation of the antioxidant activity of red wines in relationship to their phenolic content. Ital J Food Sci 17, 381–393.

    CAS  Google Scholar 

  • Klatsky AL, Koplik S, Kipp H, Friedman GD (2008). The confounded relation of coffee drinking to coronary artery disease. Am J Cardiol 101, 825–827.

    Article  Google Scholar 

  • Namdar M, Schepis T, Koepfli P, Gaemperli O, Siegrist PT, Grathwohl R et al. (2009). Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls. PloS ONE 4, 1–6.

    Article  Google Scholar 

  • Parras P, Martỳnez-Tome M, Jimenez AM, Murcia MA (2007). Antioxidant capacity of coffees of several origins brewed following three different procedures. Food Chem 102, 582–592.

    CAS  Article  Google Scholar 

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Correspondence to S Buscemi.

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Buscemi, S., Batsis, J., Arcoleo, G. et al. Coffee and endothelial function: a battle between caffeine and antioxidants?. Eur J Clin Nutr 64, 1242–1243 (2010). https://doi.org/10.1038/ejcn.2010.137

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  • DOI: https://doi.org/10.1038/ejcn.2010.137

Keywords

  • coffee
  • antioxidants
  • caffeine
  • FMD

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